INT118400

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.78
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 10 99.78 Very High Very High Very High
diclofenac 11 95.04 Very High Very High Very High
cytokine 10 94.32 High High
Sciatic nerve 1 89.68 High High
Peripheral nervous system 1 70.72 Quite High
Inflammation 1 68.52 Quite High
cINOD 1 37.64 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 10 99.78 Very High Very High Very High
Hepatotoxicity 8 95.96 Very High Very High Very High
Disease Susceptibility 1 95.88 Very High Very High Very High
Necrosis 1 84.36 Quite High
Cancer 1 84.00 Quite High
Syndrome 1 73.00 Quite High
Demyelinating Disease 1 69.40 Quite High
INFLAMMATION 2 68.52 Quite High
Liver Failure 1 66.04 Quite High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with disease susceptibility.
Positive_regulation (resulting) of Transcription (transcription) of IL-4 associated with disease susceptibility
1) Confidence 0.35 Published 2004 Journal Hepatology Section Abstract Doc Link 15122773 Disease Relevance 0.68 Pain Relevance 0.39
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Positive_regulation (levels) of Transcription (expression) of IL-4 associated with neuritis
2) Confidence 0.20 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.10 Pain Relevance 1.14

General Comments

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