INT118407

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.94
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tac2)
Tac2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 89.04 High High
Pain 4 84.16 Quite High
substance P 33 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematological Disease 4 96.92 Very High Very High Very High
Pain 4 84.16 Quite High
Eclampsia 7 74.12 Quite High
Reprotox - General 1 3 5.00 Very Low Very Low Very Low
Hypogonadotropic Hypogonadism 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Endometriosis (extended) 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1.
Transcription (transcription) of Neurokinin-B
1) Confidence 0.60 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15123623 Disease Relevance 0.25 Pain Relevance 0.08
Genetic complementation analysis in GATA-1-null G1E cells revealed that endogenous GATA-2 occupied the same region of intron-7, and expression of ER-GATA-1 displaced GATA-2 and activated Tac-2 transcription.
Transcription (transcription) of Tac-2
2) Confidence 0.60 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15123623 Disease Relevance 0.20 Pain Relevance 0.07
We found that GATA-1 strongly activates transcription of the Tac-2 gene, which encodes proneurokinin-B, a precursor of neurokinin-B (NK-B).
Transcription (transcription) of Tac-2
3) Confidence 0.60 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15123623 Disease Relevance 0.26 Pain Relevance 0.08
Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1.
Transcription (transcription) of Neurokinin-B
4) Confidence 0.57 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15123623 Disease Relevance 0.25 Pain Relevance 0.08
Tac2 and Tacr3 mRNA levels were decreased by estrogen at both 3 and 24 h.
Transcription (levels) of Tac2
5) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.09
The transcripts for Tac1, Tac2, Tac4, Tacr1, Tacr2 and Tacr3 were detected in uteri from ovariectomized mice.
Transcription (transcripts) of Tac2
6) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
The transcripts for Tac1, Tac2, Tac4, Tacr1, Tacr2 and Tacr3 were detected in uteri from ovariectomized mice.
Transcription (detected) of Tac2
7) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0

General Comments

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