INT118440

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 28
Disease Relevance 7.33
Pain Relevance 6.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TRPV4) plasma membrane (TRPV4) transmembrane transport (TRPV4)
Anatomy Link Frequency
neurons 2
spinal cord 1
kidney 1
neuronal 1
peripheral nerve 1
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 166 100.00 Very High Very High Very High
Spinal cord 77 99.92 Very High Very High Very High
dorsal root ganglion 224 98.72 Very High Very High Very High
Dorsal horn 7 98.66 Very High Very High Very High
Calcium channel 1 98.36 Very High Very High Very High
diabetic neuropathy 56 97.44 Very High Very High Very High
agonist 68 97.28 Very High Very High Very High
Pain 265 96.92 Very High Very High Very High
Inflammation 40 96.44 Very High Very High Very High
imagery 15 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 31 99.36 Very High Very High Very High
Liver Cancer 3 98.88 Very High Very High Very High
Ganglion Cysts 239 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 8 98.56 Very High Very High Very High
Diabetic Neuropathy 56 97.44 Very High Very High Very High
Pain 203 96.92 Very High Very High Very High
Diabetes Mellitus 178 96.72 Very High Very High Very High
Injury 140 96.52 Very High Very High Very High
INFLAMMATION 51 96.44 Very High Very High Very High
Hyperalgesia 33 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we compared the contribution of capsaicin-sensitive TRPV1 channels to cell migration with that of mechanosensitive TRPV4 channels that are also expressed in HepG2 cells.
Gene_expression (expressed) of TRPV4 associated with qutenza
1) Confidence 0.71 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17184838 Disease Relevance 0.14 Pain Relevance 0.95
According to the results for the 30 healthy donors, we can conclude that TRPV3 is the least expressed gene of this pool, followed by TRPV4, TRPV1 and TRPV2 (Fig. 1).
Gene_expression (expressed) of TRPV4
2) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0 Pain Relevance 0
To investigate the interaction in the full-length channel protein, we used a TRPV4 expression construct in which CFP and YFP were fused to the N- and C termini, respectively (Fig. 5).
Gene_expression (expression) of TRPV4
3) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
TRPV4 is highly expressed in kidney and was originally found to be activated by hypotonic solutions, suggesting a role in renal osmoregulation [12], [13], [14].
Gene_expression (expressed) of TRPV4 in kidney
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.15
TRPV4 was present in injured roots, both dorsal and ventral (Fig 6B), but was weak in motor neurons and fibres in the ventral horns.
Gene_expression (present) of TRPV4 in ventral
5) Confidence 0.62 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.34 Pain Relevance 0.41
TRPV3 was classified as the least expressed gene of the pool, followed by TRPV1 and TRPV4 (respectively 2.28 and 4.83 times more expressed than TRPV3).
Gene_expression (expressed) of TRPV4
6) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0.08 Pain Relevance 0.08
Truncation of TRPV1, expression of cytosolic termini of TRPV1 or TRPV4 and construction of chimeric TRPV channel subunits revealed that the specificity and the affinity of the subunit interaction is synergistically provided by interaction modules located in the transmembrane domains and in the cytosolic termini.
Gene_expression (expression) of TRPV4
7) Confidence 0.58 Published 2005 Journal J. Cell. Sci. Section Abstract Doc Link 15713749 Disease Relevance 0.07 Pain Relevance 0.10
CONCLUSION: TNF-alpha provides differentially enhanced synoviocyte TRPV1 and TRPV4 expression and [Ca2+]i response dependent on the TRP stimulus and time after exposure.
Gene_expression (expression) of TRPV4
8) Confidence 0.58 Published 2009 Journal Molecular pain Section Body Doc Link 19695100 Disease Relevance 0 Pain Relevance 0
TNF-alpha increases TRPV1 (8 hr peak) and TRPV4 (12 hr peak) immunostaining, mRNA and protein expression, with a TRPV1 shift to membrane fractions.
Gene_expression (expression) of TRPV4
9) Confidence 0.58 Published 2009 Journal Molecular pain Section Body Doc Link 19695100 Disease Relevance 0.11 Pain Relevance 0
Two heat sensitive channels, TRPV1 and TRPV4, and a cold-sensitive channel, TRPA1, were detected by RT-PCR.
Gene_expression (detected) of TRPV4
10) Confidence 0.55 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16597917 Disease Relevance 0.20 Pain Relevance 0.35
While TRPV4 mutants that are CaM binding-deficient result in currents that are small and do not potentiate secondary to rises in the intracellular Ca2+ concentration [11], mutants in which the interaction is absent result in large currents in the absence of Ca2+ (Fig. 6).
Gene_expression (mutants) of TRPV4
11) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
CaM slightly increased the TRPV4 response to Ca2+, but the increase is not statistically significant, indicating that in HEK cells, the CaM concentration is not a limiting factor in TRPV4 potentiation.
Gene_expression (response) of TRPV4
12) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.03
This is in good agreement with a previous study [11] that demonstrated that TRPV4 mutants in which CaM binding to the C terminus is abolished result in channels not potentiated by Ca2+ addition.
Gene_expression (mutants) of TRPV4
13) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
We measured the current increase on adding Ca2+ (2 mM) in HEK293 cells expressing YFP (not shown) or TRPV4 alone (control), or TRPV4 together with CaM or CaM mutants (Fig. 1F).
Gene_expression (expressing) of TRPV4
14) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.08
We measured the current increase on adding Ca2+ (2 mM) in HEK293 cells expressing YFP (not shown) or TRPV4 alone (control), or TRPV4 together with CaM or CaM mutants (Fig. 1F).
Gene_expression (expressing) of TRPV4
15) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.08
Few TRPV4-immunopositive nerve fibres were detected in skin samples.
Gene_expression (detected) of TRPV4 in skin
16) Confidence 0.54 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.49 Pain Relevance 0.03
While the expression of the TRPV1–4 genes has been adequately proved in skin, sensory fibres and keratinocytes, less is known about TRPV3 and TRPV4 expression in human blood cells.


Gene_expression (expression) of TRPV4 in blood cells
17) Confidence 0.53 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2588574 Disease Relevance 0.19 Pain Relevance 0.18
The recently discovered vanilloid thermoreceptors TRPV3 and TRPV4, which are also expressed by sensory fibres and activated by warmth, were also studied [17,18].


Gene_expression (expressed) of TRPV4 associated with increased venous pressure under development
18) Confidence 0.52 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.06 Pain Relevance 0.95
The same was found in cells cotransfected with CFP-TRPV4 and TRPV4-YFP (Fig. 5B) suggesting that interactions can occur between subunits in the homotetrameric channel.
Gene_expression (cotransfected) of TRPV4-YFP
19) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
The same was found in cells cotransfected with CFP-TRPV4 and TRPV4-YFP (Fig. 5B) suggesting that interactions can occur between subunits in the homotetrameric channel.
Gene_expression (cotransfected) of TRPV4
20) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox