INT118465

Context Info Confidence 0.05 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.74 Pain Relevance 0.89

Anatomy Link Frequency multinucleated osteoclasts 2 Bmc1 (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 62 99.40 Eae 7 99.36 Hyperalgesia 2 97.22 Neuropathic pain 2 93.04 withdrawal 1 83.60 COX-2 inhibitor 1 75.00 Sciatic nerve 1 67.80 Inflammation 39 58.24 painful pain 1 56.20 neuralgia 3 25.00

Disease Link Frequency Relevance Heat Arthritis 127 99.84 Injury 6 99.36 Hyperalgesia 2 97.22 Neuropathic Pain 2 75.00 Body Weight 15 70.24 Osteoporosis 2 64.56 INFLAMMATION 39 58.24 Nociception 1 56.20 Obesity 10 55.76 Hypercalcemia 2 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Etodolac alleviated heat-evoked hyperalgesia in the CCI rats and the increase in number of TRAP-positive multinucleated osteoclasts on the CCI-side was abrogated, however, it did not inhibit the decrease of BMC and BMD on the CCI-side.

Negative_regulation (inhibit) of Negative_regulation (decrease) of BMC in multinucleated osteoclasts associated with hyperalgesia and eae

1) Confidence 0.05 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126127 Disease Relevance 0.85 Pain Relevance 0.74

The loss of BMC was partly prevented in arthritic animals treated with 10 mg/kg/day of rosiglitazone or 30 mg/kg/day of pioglitazone (Figure 6a).

Negative_regulation (prevented) of Negative_regulation (loss) of BMC associated with arthritis

2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.89 Pain Relevance 0.15

General Comments

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