INT118465

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.74
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
multinucleated osteoclasts 2
Bmc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 62 99.40 Very High Very High Very High
Eae 7 99.36 Very High Very High Very High
Hyperalgesia 2 97.22 Very High Very High Very High
Neuropathic pain 2 93.04 High High
withdrawal 1 83.60 Quite High
COX-2 inhibitor 1 75.00 Quite High
Sciatic nerve 1 67.80 Quite High
Inflammation 39 58.24 Quite High
painful pain 1 56.20 Quite High
neuralgia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Arthritis 127 99.84 Very High Very High Very High
Injury 6 99.36 Very High Very High Very High
Hyperalgesia 2 97.22 Very High Very High Very High
Neuropathic Pain 2 75.00 Quite High
Body Weight 15 70.24 Quite High
Osteoporosis 2 64.56 Quite High
INFLAMMATION 39 58.24 Quite High
Nociception 1 56.20 Quite High
Obesity 10 55.76 Quite High
Hypercalcemia 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etodolac alleviated heat-evoked hyperalgesia in the CCI rats and the increase in number of TRAP-positive multinucleated osteoclasts on the CCI-side was abrogated, however, it did not inhibit the decrease of BMC and BMD on the CCI-side.
Negative_regulation (inhibit) of Negative_regulation (decrease) of BMC in multinucleated osteoclasts associated with hyperalgesia and eae
1) Confidence 0.05 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126127 Disease Relevance 0.85 Pain Relevance 0.74
The loss of BMC was partly prevented in arthritic animals treated with 10 mg/kg/day of rosiglitazone or 30 mg/kg/day of pioglitazone (Figure 6a).
Negative_regulation (prevented) of Negative_regulation (loss) of BMC associated with arthritis
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.89 Pain Relevance 0.15

General Comments

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