INT118469

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.98
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgfr3) nucleus (Fgfr3) kinase activity (Fgfr3)
cell-cell signaling (Fgfr3) lysosome (Fgfr3) cytoplasm (Fgfr3)
Anatomy Link Frequency
temporomandibular joint 1
fibroblast 1
keratinocytes 1
Fgfr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 10 98.40 Very High Very High Very High
Inflammatory response 15 69.76 Quite High
Inflammation 80 5.00 Very Low Very Low Very Low
cytokine 28 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
member 8 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Synovial Chondromatosis 14 99.84 Very High Very High Very High
Multiple Myeloma 14 98.86 Very High Very High Very High
Lymphatic System Cancer 244 98.80 Very High Very High Very High
Primary Sclerosing Cholangitis 16 98.44 Very High Very High Very High
Temporomandibular Joint Syndrome 10 98.40 Very High Very High Very High
Disease 49 97.88 Very High Very High Very High
Targeted Disruption 42 94.80 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 30 90.28 High High
Diffuse Large B-cell Lymphoma 112 87.44 High High
Congenital Anomalies 36 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FGFR3 is also expressed in keratinocytes, particularly in the suprabasal layers (LogiƩ et al., 2005).
Gene_expression (expressed) of FGFR3 in keratinocytes
1) Confidence 0.72 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.22 Pain Relevance 0.03
Fgfr3 and Fgfr4 cDNAs were used as templates (Steiling et al., 2003).


Gene_expression (cDNAs) of Fgfr3
2) Confidence 0.62 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.07 Pain Relevance 0
There was no compensatory up-regulation of Fgfr3 expression, and Fgfr4 mRNA could not be detected in mice of all genotypes using an RNase protection assay (Fig. 1 C).
Gene_expression (expression) of Fgfr3
3) Confidence 0.56 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.30 Pain Relevance 0
The expression of fibroblast growth factor receptor-3 in synovial osteochondromatosis of the temporomandibular joint.
Gene_expression (expression) of fibroblast growth factor receptor-3 in temporomandibular joint associated with snapping jaw and synovial chondromatosis
4) Confidence 0.44 Published 2004 Journal Arch. Oral Biol. Section Title Doc Link 15126141 Disease Relevance 1.79 Pain Relevance 0.40
It was reported recently that expression of fibroblast growth factor receptor-3 (FGFR-3) was observed specifically in PSC.
Gene_expression (expression) of fibroblast growth factor receptor-3 in fibroblast associated with primary sclerosing cholangitis
5) Confidence 0.44 Published 2004 Journal Arch. Oral Biol. Section Abstract Doc Link 15126141 Disease Relevance 1.44 Pain Relevance 0.31
Since recently developed drugs that target the antifibroblast growth factor receptor 3 (FGFR3) pathway are being tested in multiple myeloma in which about 15% cases carry the t(4;14) resulting in overexpression of FGFR3, Larson et al. analyzed 70 cases of malignant lymphoma.
Gene_expression (overexpression) of FGFR3 associated with lymphatic system cancer and multiple myeloma
6) Confidence 0.30 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.53 Pain Relevance 0
Only weak to moderate expression was found in 12% of cases, so it is unlikely that FGFR3 targeting is an effective treatment in lymphomas as well [9].
Gene_expression (targeting) of FGFR3 associated with lymphatic system cancer
7) Confidence 0.26 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.62 Pain Relevance 0

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