INT118476

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.93
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (Rpl3) ribosome (Rpl3) nucleolus (Rpl3)
intracellular (Rpl3) translation (Rpl3) cytoplasm (Rpl3)
Anatomy Link Frequency
neurons 3
spinal cord 1
nerve 1
Rpl3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 309 99.72 Very High Very High Very High
Eae 53 99.54 Very High Very High Very High
Spinal cord 142 98.88 Very High Very High Very High
Inflammation 167 98.80 Very High Very High Very High
orphanin 8 98.54 Very High Very High Very High
Peripheral nerve injury 56 97.68 Very High Very High Very High
Sciatic nerve 43 97.16 Very High Very High Very High
Neuropathic pain 27 93.84 High High
Hyperalgesia 1 87.60 High High
allodynia 17 87.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 309 99.72 Very High Very High Very High
INFLAMMATION 200 98.80 Very High Very High Very High
Nervous System Injury 113 97.68 Very High Very High Very High
Neuropathic Pain 86 93.84 High High
Hyperalgesia 3 87.60 High High
Nociception 25 82.68 Quite High
Pain 52 66.12 Quite High
Inflammatory Pain 4 57.36 Quite High
Brain Hemorrhage 1 56.20 Quite High
Hypersensitivity 31 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten days after nerve ligation, there was a 2.46+/-0.38 fold ( p<0.05) bilateral increase in nociceptin immunoreactivity in the lamina superficiales (I and II), with a notable increase in the inner lamina II at the level of L4.
Positive_regulation (increase) of L4 in nerve associated with orphanin
1) Confidence 0.37 Published 2004 Journal Anaesthesist Section Abstract Doc Link 15127152 Disease Relevance 0.68 Pain Relevance 1.30
However, we find that phospho p70S6K, CGRP immunoreactivity are actually maintained in what should be partly denervated L4 of SNL animals.
Positive_regulation (denervated) of L4
2) Confidence 0.20 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.13 Pain Relevance 0.12
Immunostaining showed that only ~2% of DRG neurons were positive for PAP-II in L4 and L5 DRGs on the contralateral side after unilateral axotomy of the sciatic nerve (Fig. 5A and 5B), similar to that found in the DRGs of normal rats.
Positive_regulation (positive) of L4 in neurons associated with dorsal root ganglion and sciatic nerve
3) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.62 Pain Relevance 0.92
However, the number of PAP-II-immunoreactive neurons was markedly increased in L4 and L5 DRGs after peripheral inflammation induced by intraplantar CFA injection (Fig. 3A and 3B).
Positive_regulation (increased) of L4 in neurons associated with inflammation
4) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.57 Pain Relevance 0.75
However, the number of PAP-II-immunoreactive neurons was markedly increased in the ipsilateral L4 and L5 DRGs (Fig. 5A and 5B).
Positive_regulation (increased) of L4 in neurons
5) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.52 Pain Relevance 0.87
SNL surgery significantly increased OX-42 immunoreactivity in the L4-L6 sections of ipsilateral spinal cord of chronic vehicle-treated rats, compared to the contralateral spinal cord, indicative of spinal microglia activation (Fig 2, OX-42 immunoreactivity, ipsilateral-vehicle, 30.2 ± 0.5; contralateral-vehicle, 17.0 ± 0.3).
Positive_regulation (increased) of L4 in spinal cord associated with eae and spinal cord
6) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2719614 Disease Relevance 0.40 Pain Relevance 0.83

General Comments

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