INT118482

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Fasn) lyase activity (Fasn) oxidoreductase activity (Fasn)
Golgi apparatus (Fasn) biosynthetic process (Fasn) plasma membrane (Fasn)
Anatomy Link Frequency
liver 1
apoptotic cells 1
Fasn (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 30 74.40 Quite High
Inflammation 30 58.16 Quite High
Paracetamol 3 50.00 Quite Low
cytokine 6 25.68 Quite Low
agonist 9 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Cholecystokinin 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mental Disorders 4 79.20 Quite High
Pain 12 74.40 Quite High
Disease 11 72.24 Quite High
Adrenoleukodystrophy 1 71.60 Quite High
Targeted Disruption 17 69.28 Quite High
Injury 4 68.84 Quite High
INFLAMMATION 34 58.16 Quite High
Cancer 7 51.52 Quite High
Arrhythmia Under Development 1 50.32 Quite High
Hypolipidemia 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.
Negative_regulation (downregulated) of Fas mRNA in apoptotic cells
1) Confidence 0.31 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.07 Pain Relevance 0
During the last 50 to 100 years the typical Western diet has contained increasing amounts of n-6 FAs and decreasing amounts of n-3 FAs [6].
Negative_regulation (decreasing) of FAs
2) Confidence 0.25 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1471788 Disease Relevance 0.64 Pain Relevance 0.18
Experiments with liver-specific inactivation of fatty-acid synthase (FAS) suggest that products of FAS serve as endogenous activators of PPAR?
Negative_regulation (inactivation) of fatty-acid synthase in liver
3) Confidence 0.10 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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