INT118483

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.21
Pain Relevance 0

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mitochondrion (Fasn) lyase activity (Fasn) oxidoreductase activity (Fasn)
Golgi apparatus (Fasn) biosynthetic process (Fasn) plasma membrane (Fasn)
Anatomy Link Frequency
apoptotic cells 6
Fasn (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 6 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.
Negative_regulation (prevented) of Gene_expression (expression) of Fas mRNA in apoptotic cells
1) Confidence 0.42 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.
Negative_regulation (downregulated) of Gene_expression (expression) of Fas mRNA in apoptotic cells
2) Confidence 0.31 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.
Negative_regulation (decreased) of Gene_expression (expression) of Fas mRNA in apoptotic cells
3) Confidence 0.31 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.07 Pain Relevance 0

General Comments

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