INT118490

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNOT4) RNA binding (CNOT4) nucleus (CNOT4)
ligase activity (CNOT4) cytoplasm (CNOT4)
Anatomy Link Frequency
platelet 1
CNOT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 1 94.32 High High
Pain 7 83.76 Quite High
TRP channel 1 75.76 Quite High
qutenza 2 73.84 Quite High
cva 24 63.00 Quite High
Nerve growth factor 1 41.28 Quite Low
Inflammation 3 34.40 Quite Low
diabetic neuropathy 1 26.40 Quite Low
spastic colon 1 25.00 Low Low
Neuropathic pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 6 97.88 Very High Very High Very High
Pain 6 83.76 Quite High
Hemorrhage 13 82.72 Quite High
Peripheral Arterial Disease 12 80.96 Quite High
Hematoma 1 77.76 Quite High
Cv General 3 Under Development 10 63.00 Quite High
Disease 7 50.80 Quite High
Pressure Volume 2 Under Development 1 40.92 Quite Low
Hepatic Insufficiency 1 38.80 Quite Low
Pressure And Volume Under Development 1 36.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heparin-induced thrombocytopenia (HIT) is another well known complication of heparin, its incidence being approximately 0.8%, with LMWH, about 3-fold lower than with UFH.67,68 HIT is caused by heparin-dependent antibodies (usually immunoglobulin G) binding a confirmationally modified epitope on platelet factor 4 (PF4), its modified structure being subsequently recognized as a foreign protein by the immunocompetent cells of the patients.
Regulation (epitope) of factor 4 in platelet associated with heparin-induced thrombocytopenia
1) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762431 Disease Relevance 1.18 Pain Relevance 0.12
It is not clear, however, whether phosphorylation per se is sufficient to liberate TRPV1 under the inhibitory control of phosphatydylinositol-4,5-bisphosphate.
Regulation (control) of phosphatydylinositol-4
2) Confidence 0.01 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128291 Disease Relevance 0 Pain Relevance 0.16

General Comments

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