INT118492

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 7
Total Number 11
Disease Relevance 6.32
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
pleural cavity 1
cerebral cortex 1
brain 1
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 24 100.00 Very High Very High Very High
Desipramine 6 100.00 Very High Very High Very High
fluoxetine 3 100.00 Very High Very High Very High
cerebral cortex 9 99.88 Very High Very High Very High
addiction 3 99.84 Very High Very High Very High
Inflammation 181 99.76 Very High Very High Very High
Hippocampus 12 99.48 Very High Very High Very High
cytokine 66 99.08 Very High Very High Very High
Inflammatory response 21 99.02 Very High Very High Very High
fibrosis 189 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 188 99.76 Very High Very High Very High
Disease 17 98.68 Very High Very High Very High
Pulmonary Disease 13 98.56 Very High Very High Very High
Pulmonary Fibrosis 112 98.36 Very High Very High Very High
Asthma 5 98.20 Very High Very High Very High
Apoptosis 6 98.00 Very High Very High Very High
Fibrosis 81 97.08 Very High Very High Very High
Rheumatoid Arthritis 17 95.84 Very High Very High Very High
Hypertension 4 94.44 High High
Pneumonia 28 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the present results suggest some species-dependence of the regulation of PDE4 subtypes, based on data obtained previously using rats.
Regulation (regulation) of PDE4 associated with addiction
1) Confidence 0.61 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.80
In mouse hippocampus and cerebral cortex, the effects of repeated treatment with the antidepressants desipramine and fluoxetine or the PDE4 inhibitor rolipram on the expression of PDE4D was compared to that of PDE4A and PDE4B, the other two subtypes expressed in the brain.
Regulation (effects) of PDE4 in brain associated with desipramine, antidepressant, hippocampus, cerebral cortex and fluoxetine
2) Confidence 0.44 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.65
Thus, PDE4-mediated regulation of cAMP levels could underlie the establishment of reward valence to abused drugs.
Regulation (regulation) of PDE4
3) Confidence 0.37 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15128409 Disease Relevance 0 Pain Relevance 0.76
In cerebral cortex, antidepressants increased PDE4A and did not change PDE4B, whereas ROL did not change PDE4A and increased PDE4B. 3H-Rolipram binding was increased in cytosolic, but not in membrane, fractions of cerebral cortex by all drugs tested; there were no changes observed in hippocampus.
Neg (not) Regulation (change) of PDE4A in cerebral cortex associated with antidepressant, hippocampus and cerebral cortex
4) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.84
Thus, we suggested positive effect of PDE4 inhibition on inflammatory component of PF.
Regulation (effect) of PDE4 associated with fibrosis and inflammation
5) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.84 Pain Relevance 0.73
However, it was previously reported that PDE4 inhibitors have little or no effect on production of this cytokine [35].
Neg (little) Regulation (effect) of PDE4 associated with cytokine
6) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.70 Pain Relevance 0.46
All together these data suggest that the effects observed in present study might be accounted to several independent actions of the PDE4 inhibitor, affecting both inflammatory process and the effector cells at the site of ongoing fibrosis.


Regulation (affecting) of PDE4 associated with fibrosis and inflammation
7) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.89 Pain Relevance 0.40
Given that PDE4 is the major cAMP-hydrolyzing enzyme in inflammatory cells and that it is necessary for developing of inflammatory response [8,14,15,25], several studies showed beneficial effect of PDE4 inhibitors on such inflammatory diseases as asthma and chronic obstructive pulmonary disease (COPD) [16].
Regulation (effect) of PDE4 associated with asthma, inflammatory response, pulmonary disease, inflammation and disease
8) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.84 Pain Relevance 0.72
Here, we examined the effects of specific PDE4 inhibition on the resolution of neutrophilic inflammation in the pleural cavity of LPS-challenged mice.
Spec (examined) Regulation (effects) of PDE4 in pleural cavity associated with inflammation
9) Confidence 0.15 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.60 Pain Relevance 0.26
The purpose of this study is to elucidate the effects of phosphodiesterase 4 (PDE4) inhibitors in a new animal model for the evaluation of pannus formation and cytokine production in the pannus.
Regulation (effects) of PDE4 associated with cytokine
10) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC2233982 Disease Relevance 0.45 Pain Relevance 0.35
Although reduction of PDE4 or calcineurin to 20% of the default amount had little effect on the Ca2+ threshold (PDE4, 0.50±0.08 ?
Neg (little) Regulation (effect) of PDE4
11) Confidence 0.01 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.08

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