INT118511

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 15
Disease Relevance 0.76
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pard3) cytoskeleton (Pard3) cell cycle (Pard3)
cell division (Pard3) protein complex (Pard3) cytoplasm (Pard3)
Anatomy Link Frequency
neurons 7
Pard3 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 156 97.72 Very High Very High Very High
neuropeptide release 22 92.04 High High
Inflammation 136 92.00 High High
agonist 156 90.24 High High
nociceptor 176 82.00 Quite High
IPN 1 75.00 Quite High
Spinal cord 1 68.48 Quite High
Calcitonin gene-related peptide 220 65.72 Quite High
Neuropeptide 132 65.20 Quite High
bradykinin 44 59.68 Quite High
Disease Link Frequency Relevance Heat
Nociception 232 92.48 High High
INFLAMMATION 145 92.00 High High
Inflammatory Pain 1 75.00 Quite High
Neurogenic Inflammation 22 64.24 Quite High
Hyperalgesia 33 19.36 Low Low
Pain 67 5.00 Very Low Very Low Very Low
Injury 33 5.00 Very Low Very Low Very Low
Targeted Disruption 33 5.00 Very Low Very Low Very Low
Coagulation Disorder 22 5.00 Very Low Very Low Very Low
Rupture 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T7-tagged PAR3 mutants overexpressed in 293T cells specifically interacted with GST–nephrinICD, except for the mutants lacking all PDZ domains or mutated in the third PDZ domain [27], [28], indicating the third PDZ domain is required for the formation of the complex with nephrin (Figure 6B).
Gene_expression (overexpressed) of PAR3
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Purified GST–nephrinICD2 precipitated the three PDZ domains of PAR3 fused with maltose binding protein (MBP–PDZ123) (Figure 6, A and C).
Gene_expression (precipitated) of PAR3
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Purified GST fusion proteins were separately incubated for 2 h at 4°C with 293T cells expressing the PAR3 proteins extracted with 25 mM Tris-HCl (pH 8.0), 100 mM NaCl, 5 mM EDTA, 1% TritonX-100, and protease inhibitor cocktail (Sigma), or with purified MBP-fusion proteins in 20 mM HEPES–NaOH (pH 7.5), 100 mM NaCl, 5 mM EDTA, 1% TritonX-100, 0.5 mg/ml bovine serum albumin, and 10% glycerol.
Gene_expression (expressing) of PAR3
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
Following desensitization of PAR1 and PAR4, calcium signals in response to thrombin are seen in only a very small number of neurons, far smaller than the proportion in which histological studies had shown expression of PAR3.
Gene_expression (expression) of PAR3 in neurons
4) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.10
PAR3 mRNA was intensely expressed in many DRG neurons and the mRNAs for PAR1, PAR2 and PAR4 were more weakly expressed.
Gene_expression (expressed) of PAR3 mRNA in neurons
5) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.06
PAR3 is highly expressed in DRG neurons (Fig. 1).
Gene_expression (expressed) of PAR3 in neurons
6) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0.23
However, within these limitations it seems clear that the expression of PAR3 is much more intense than that of PAR1, 2 and 4.
Gene_expression (expression) of PAR3
7) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
PAR3 was present in 49.5 ± 4.5% of neurons and was expressed mainly in neurones with a small cross-sectional area, but unlike PAR2, PAR3 mRNA was also expressed in medium-sized neurones.
Gene_expression (expressed) of PAR3 mRNA in neurons
8) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
PAR3 was present in 49.5 ± 4.5% of neurons and was expressed mainly in neurones with a small cross-sectional area, but unlike PAR2, PAR3 mRNA was also expressed in medium-sized neurones.
Gene_expression (expressed) of PAR3 in neurons
9) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
PAR3 was present in 49.5 ± 4.5% of neurons and was expressed mainly in neurones with a small cross-sectional area, but unlike PAR2, PAR3 mRNA was also expressed in medium-sized neurones.
Gene_expression (present) of PAR3 in neurons
10) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
Note that the percentage of neurons from PAR1-/- mice responding to thrombin is similar to the proportion of neurons expressing PAR4 by ISH (14.5%, see Fig. 1C above) but is very much smaller than the proportion expressing PAR3 by both ISH and immunohistochemistry (49.5% and 42.03% respectively, see Fig. 1C,D above).
Gene_expression (expressing) of PAR3 in neurons
11) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0.29
Here, we show that TRPV1 is coexpressed with PAR2 but not with PAR1 or PAR3, and that TRPV1 can functionally interact with PAR2.
Neg (not) Gene_expression (coexpressed) of PAR3
12) Confidence 0.29 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128843 Disease Relevance 0.26 Pain Relevance 0.43
PAR3

PAR3 was strongly expressed, mainly in small neurones (Fig. 1).

Gene_expression (expressed) of PAR3
13) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.13 Pain Relevance 0.25
PAR3

PAR3 was strongly expressed, mainly in small neurones (Fig. 1).

Gene_expression (expressed) of PAR3
14) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.13 Pain Relevance 0.25
The percentages of neurones expressing PAR3 determined by in situ hybridization and immunohistochemistry were in good agreement (49% and 42%, respectively).
Gene_expression (expressing) of PAR3
15) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.12 Pain Relevance 0.24

General Comments

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