INT118512

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 33
Total Number 73
Disease Relevance 26.56
Pain Relevance 18.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
neurons 14
brain 6
neuronal 5
platelets 2
sensory neurons 2
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 36 100.00 Very High Very High Very High
nociceptor 608 99.98 Very High Very High Very High
Inflammation 1246 99.72 Very High Very High Very High
Inflammatory response 118 99.48 Very High Very High Very High
Analgesic 77 99.48 Very High Very High Very High
Nerve growth factor 592 99.46 Very High Very High Very High
substance P 301 99.44 Very High Very High Very High
qutenza 536 98.82 Very High Very High Very High
c fibre 47 98.76 Very High Very High Very High
Pain 249 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Penetrating Head Injuries 75 99.76 Very High Very High Very High
INFLAMMATION 1501 99.72 Very High Very High Very High
Brain Injury 150 99.72 Very High Very High Very High
Injury 1003 99.66 Very High Very High Very High
Overactive Bladder 72 99.60 Very High Very High Very High
Nociception 806 99.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 99.12 Very High Very High Very High
Viral Meningitis 15 98.96 Very High Very High Very High
Coagulation Disorder 84 98.72 Very High Very High Very High
Targeted Disruption 146 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent report documents upregulated PAR-1 expression in astrocytes during HIV encephalitis [58].
Gene_expression (expression) of PAR-1 in astrocytes associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
1) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.74 Pain Relevance 0.08
The level of PAR-1 protein expression after IL-1?
Gene_expression (expression) of PAR-1 protein
2) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.07
on PAR-1 expression were assessed in vitro.
Gene_expression (expression) of PAR-1
3) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.68 Pain Relevance 0.07
The level of PAR-1 expression trended towards increasing in the astrocyte cultures; the level was unchanged in mixed glial cultures, the level was very low in the cortical neuronal cultures and below the level of detection in the microglial cultures.
Gene_expression (expression) of PAR-1 in neuronal
4) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.54 Pain Relevance 0.06
Therefore, we analyzed the expression of PAR-1 following penetrating brain injury.
Spec (analyzed) Gene_expression (expression) of PAR-1 in brain associated with penetrating head injuries
5) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.86 Pain Relevance 0.09
To determine which cell type is induced to express PAR-1, the effects of IL-1?
Gene_expression (express) of PAR-1
6) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.69 Pain Relevance 0.07
The PAR-1 expression was dramatically increased in the WT mice at 3 days post injury (Fig. 3).
Gene_expression (expression) of PAR-1 associated with injury
7) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.85 Pain Relevance 0.09
To elucidate which cell type expresses PAR-1 protein, we performed immunofluorescence staining of PAR-1 on the brain sections.
Gene_expression (expresses) of PAR-1 protein in brain
8) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.65 Pain Relevance 0.08
Altogether, these results suggest that brain cells are not responsible for the induction of PAR-1 expression after traumatic brain injury.
Gene_expression (expression) of PAR-1 in brain associated with brain injury
9) Confidence 0.63 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.03
The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.
Gene_expression (levels) of PAR-1
10) Confidence 0.55 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.89 Pain Relevance 0.17
We also examined the expression of the protease-activated receptor 1 (PAR-1) in wild type (WT) and IL-1R1-null mice following a neocortical penetrating injury as this receptor has been implicated in astrocyte hyperplasia after brain injury [41].
Spec (examined) Gene_expression (expression) of PAR-1 in brain associated with injury, brain injury and hyperplasia
11) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.81 Pain Relevance 0.15
We also examined the expression of the protease-activated receptor 1 (PAR-1) in wild type (WT) and IL-1R1-null mice following a neocortical penetrating injury as this receptor has been implicated in astrocyte hyperplasia after brain injury [41].
Spec (examined) Gene_expression (expression) of protease-activated receptor 1 in brain associated with injury, brain injury and hyperplasia
12) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.81 Pain Relevance 0.15
at 5 ng/ml was used to stimulate primary cultures of mixed glia, astrocytes, microglia and cortical neurons, and the expression of PAR-1 proteins was assayed.
Gene_expression (expression) of PAR-1 in neurons
13) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.52 Pain Relevance 0.06
Therefore, we performed in vitro studies to examine which brain cell increases PAR-1 expression in response to IL-1?
Gene_expression (expression) of PAR-1 in brain
14) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.52 Pain Relevance 0.06
However, following acute and chronic inflammation, probably because of the shedding of urothelial cells bearing PARs, both PAR1 and PAR2 expression are reduced [24].
Gene_expression (expression) of PAR1 in urothelial cells associated with inflammation
15) Confidence 0.49 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.51 Pain Relevance 0.28
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [27].
Gene_expression (expressed) of PAR1 in peripheral nerves associated with overactive bladder
16) Confidence 0.49 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.40 Pain Relevance 0.09
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [24].
Gene_expression (expressed) of PAR1 in muscle associated with overactive bladder
17) Confidence 0.49 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.67 Pain Relevance 0.31
Recently, it has been reported that both thrombin-sensitive protease-activated receptor 1 (PAR-1) and platelet-derived growth factor (PDGF) are present not only in platelets, but also in the CNS, which indicates that they have various physiological functions.
Gene_expression (present) of thrombin-sensitive protease-activated receptor 1 in platelets
18) Confidence 0.48 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16251448 Disease Relevance 0.50 Pain Relevance 0.61
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [21,22].
Gene_expression (expressed) of PAR1 in peripheral nerves associated with overactive bladder
19) Confidence 0.46 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.94 Pain Relevance 0.36
However, the immunofluorescence lacked the sensitivity and specificity to determine which cell type expresses PAR-1 after neocortical injury.
Gene_expression (expresses) of PAR-1 associated with injury
20) Confidence 0.43 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.61 Pain Relevance 0.07

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