INT118516

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.63
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
HEK 4
cartilage 2
bowel 2
dorsal horn 2
mast cell 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 12 100.00 Very High Very High Very High
agonist 99 99.96 Very High Very High Very High
qutenza 16 99.96 Very High Very High Very High
Osteoarthritis 132 99.12 Very High Very High Very High
endometriosis 168 98.92 Very High Very High Very High
Inflammation 185 98.80 Very High Very High Very High
substance P 23 98.80 Very High Very High Very High
Calcitonin gene-related peptide 2 98.16 Very High Very High Very High
spastic colon 4 97.86 Very High Very High Very High
Hyperalgesia 16 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 134 100.00 Very High Very High Very High
Endometriosis 224 98.92 Very High Very High Very High
INFLAMMATION 204 98.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 97.96 Very High Very High Very High
Functional Bowel Disorder 4 97.86 Very High Very High Very High
Hyperalgesia 22 97.48 Very High Very High Very High
Diarrhoea 2 97.12 Very High Very High Very High
Pain 19 96.08 Very High Very High Very High
Neurogenic Inflammation 3 88.12 High High
Disease 49 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study

Proteinase-activated receptors (PARs) belong to a family of G protein-coupled receptors.

Positive_regulation (upregulates) of Positive_regulation (Activation) of proteinase-activated receptor 2 in cartilage associated with osteoarthritis
1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2246240 Disease Relevance 0.81 Pain Relevance 0.45
Activation of PAR2 or PKC induced phosphorylation of TRPV1 in HEK cells, suggesting a direct regulation of the channel.
Positive_regulation (induced) of Positive_regulation (Activation) of PAR2 in HEK associated with kinase c
2) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.55 Pain Relevance 1.56
PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia.
Positive_regulation (potentiated) of Positive_regulation (activation) of PAR2 in dorsal horn associated with hyperalgesia, qutenza, dorsal horn, spinal cord, calcitonin gene-related peptide and substance p
3) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.41 Pain Relevance 1.66
The effects eventually returned to baseline 12 h after stimulation, but were significant enough to qualify as evidence that PAR2 expression was upregulated in response to PAR2 agonists.
Positive_regulation (upregulated) of Positive_regulation (response) of PAR2 associated with agonist
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.13
To identify candidate genes that might be differentially expressed as a result of PAR2 activation in human embryonic kidney cells (HEK293), cDNA microarray analyses were performed using a human Compugen array of ?
Positive_regulation (result) of Positive_regulation (activation) of PAR2 in embryonic kidney
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.24 Pain Relevance 0.17
PAR2 activation induces PAR2 expression
Positive_regulation (induces) of Positive_regulation (activation) of PAR2
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.22 Pain Relevance 0.14
Indeed, according to the literature, this enzyme family appears to be responsible for the PAR-2 activation [3,4].
Positive_regulation (responsible) of Positive_regulation (activation) of PAR-2
7) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.42 Pain Relevance 0.39
BACKGROUND AND AIMS: Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) appear to have increased intestinal permeability; it has been suggested that activation of protease-activated receptor-2 (PAR-2) receptors is responsible for this alteration.
Positive_regulation (responsible) of Positive_regulation (activation) of PAR-2 in bowel associated with diarrhoea and spastic colon
8) Confidence 0.10 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 20087660 Disease Relevance 0.27 Pain Relevance 0.10
Interestingly, the activation of PAR-2 on afferent neurons, e.g., by proteases such as mast cell tryptase, leads to subsequent release of pro-inflammatory CGRP and SP [169], which might provide explanation for pain during inflammation.
Positive_regulation (leads) of Positive_regulation (activation) of PAR-2 in mast cell associated with pain, inflammation and substance p
9) Confidence 0.03 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.53 Pain Relevance 1.73

General Comments

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