INT11853

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Context Info
Confidence 0.26
First Reported 1992
Last Reported 1992
Negated 3
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.27
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
macrophages 1
monocytes 1
B-lymphocytes 1


Pain Term Frequency Confidence Heat
Inflammation 15 99.12 Very High Very High Very High
Enkephalin 3 94.32 High High
Dynorphin 3 92.48 High High
Opioid 12 91.52 High High
antinociception 9 85.88 High High
opioid receptor 3 84.36 Quite High
Endogenous opioid 6 80.08 Quite High
Pain 6 25.00 Low Low
Disease Term Frequency Confidence Heat
INFLAMMATION 9 99.12 Very High Very High Very High
Nociception 6 95.36 Very High Very High Very High
Stress 3 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats with Freund's adjuvant-induced unilateral hindpaw inflammation we show that: (i) pro-opiomelanocortin and proenkephalin-mRNAs (but not prodynorphin mRNA) are abundant in cells of inflamed, but absent in non-inflamed tissue; (ii) numerous cells infiltrating the inflamed subcutaneous tissue are stained intensely with beta-endorphin and [Met]enkephalin (but only few scattered cells with dynorphin) antibodies; (iii) beta-endorphin is present in T- and B-lymphocytes, monocytes and macrophages; and (iv) whole-body irradiation suppresses stress-induced antinociception in the inflamed paw.
Neg (absent) Gene_expression (absent) of proenkephalin-mRNAs in macrophages associated with stress, antinociception, dynorphin, inflammation and enkephalin
1) Confidence 0.26 Published 1992 Journal Neuroscience Section Abstract Doc Link 1603330 Disease Relevance 0.42 Pain Relevance 0.99
In rats with Freund's adjuvant-induced unilateral hindpaw inflammation we show that: (i) pro-opiomelanocortin and proenkephalin-mRNAs (but not prodynorphin mRNA) are abundant in cells of inflamed, but absent in non-inflamed tissue; (ii) numerous cells infiltrating the inflamed subcutaneous tissue are stained intensely with beta-endorphin and [Met]enkephalin (but only few scattered cells with dynorphin) antibodies; (iii) beta-endorphin is present in T- and B-lymphocytes, monocytes and macrophages; and (iv) whole-body irradiation suppresses stress-induced antinociception in the inflamed paw.
Neg (absent) Gene_expression (absent) of proenkephalin-mRNAs in monocytes associated with stress, antinociception, dynorphin, inflammation and enkephalin
2) Confidence 0.09 Published 1992 Journal Neuroscience Section Abstract Doc Link 1603330 Disease Relevance 0.42 Pain Relevance 0.99
In rats with Freund's adjuvant-induced unilateral hindpaw inflammation we show that: (i) pro-opiomelanocortin and proenkephalin-mRNAs (but not prodynorphin mRNA) are abundant in cells of inflamed, but absent in non-inflamed tissue; (ii) numerous cells infiltrating the inflamed subcutaneous tissue are stained intensely with beta-endorphin and [Met]enkephalin (but only few scattered cells with dynorphin) antibodies; (iii) beta-endorphin is present in T- and B-lymphocytes, monocytes and macrophages; and (iv) whole-body irradiation suppresses stress-induced antinociception in the inflamed paw.
Neg (absent) Gene_expression (absent) of proenkephalin-mRNAs in B-lymphocytes associated with stress, antinociception, dynorphin, inflammation and enkephalin
3) Confidence 0.09 Published 1992 Journal Neuroscience Section Abstract Doc Link 1603330 Disease Relevance 0.42 Pain Relevance 0.99

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