INT11854

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Context Info
Confidence 0.77
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 57
Total Number 59
Disease Relevance 30.19
Pain Relevance 38.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rl1) extracellular space (Il1rl1) extracellular region (Il1rl1)
plasma membrane (Il1rl1) intracellular (Il1rl1) molecular_function (Il1rl1)
Anatomy Link Frequency
spinal 8
brain 7
neurons 6
spinal cord 4
dorsal horn 4
Il1rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 47 99.98 Very High Very High Very High
qutenza 12 99.84 Very High Very High Very High
Pain 132 99.80 Very High Very High Very High
Inflammation 191 99.76 Very High Very High Very High
Thermal hyperalgesia 5 99.76 Very High Very High Very High
Periaqueductal grey 28 99.68 Very High Very High Very High
Cannabinoid 94 99.60 Very High Very High Very High
Hyperalgesia 127 99.58 Very High Very High Very High
nociceptor 26 99.46 Very High Very High Very High
medulla 17 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 16 99.84 Very High Very High Very High
Pain 89 99.80 Very High Very High Very High
INFLAMMATION 171 99.76 Very High Very High Very High
Hyperalgesia 133 99.76 Very High Very High Very High
Hypothermia 23 99.74 Very High Very High Very High
Urological Neuroanatomy 42 99.68 Very High Very High Very High
Neuropathic Pain 59 99.28 Very High Very High Very High
Nociception 82 99.12 Very High Very High Very High
Pseudorabies 2 98.68 Very High Very High Very High
Post Operative Pain 5 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subarachnoid administration of adenosine (AD) or AD agonists promotes sleep and induces expression of Fos protein in VLPO neurons.
Gene_expression (expression) of Fos protein in neurons associated with adenocard and agonist
1) Confidence 0.77 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831851 Disease Relevance 0 Pain Relevance 0.41
Potentiated expression of FOS protein in the rat spinal cord following bilateral noxious cutaneous stimulation.
Gene_expression (expression) of FOS protein in spinal cord associated with pain and spinal cord
2) Confidence 0.77 Published 1992 Journal Neuroscience Section Title Doc Link 1603331 Disease Relevance 0 Pain Relevance 0.23
In contrast, methoxyflurane and hypothermia blocked the appearance of the Fos protein.
Gene_expression (appearance) of Fos protein associated with hypothermia
3) Confidence 0.77 Published 1996 Journal Dev Psychobiol Section Abstract Doc Link 8872423 Disease Relevance 0.28 Pain Relevance 0.39
Compared to cutaneous CFA injection, the injection of CFA into the TMJ produced a significantly stronger inflammation associated with a selective upregulation of preprodynorphin mRNA in the trigeminal spinal complex, an enhanced medullary dorsal horn hyperexcitability, and a greater trigeminal Fos protein expression, a marker of neuronal activation.
Gene_expression (expression) of Fos protein in neuronal associated with snapping jaw, inflammation, dorsal horn and hyperexcitability
4) Confidence 0.77 Published 2001 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 11455119 Disease Relevance 1.77 Pain Relevance 1.61
This study aimed to examine the relationship between temporal and spatial expression patterns of Fos protein in the spinal dorsal horn neurons and thermal hyperalgesia behaviors in rats with chronic constriction injury (CCI) to the sciatic nerve.
Gene_expression (expression) of Fos protein in sciatic nerve associated with eae, thermal hyperalgesia, injury, sciatic nerve and dorsal horn neuron
5) Confidence 0.75 Published 2004 Journal Brain Res. Section Abstract Doc Link 15033433 Disease Relevance 0.57 Pain Relevance 0.48
Our results demonstrated that Fos protein expression in the spinal dorsal horn neurons at L5 segment ipsilateral and contralateral to CCI of the sciatic nerve was significantly greater than in sham rats from days 10 to 30 postoperatively (PO 10d to 30d), and was concentrated on the injury (ipsilateral) side.
Gene_expression (expression) of Fos protein in neurons associated with eae, injury, sciatic nerve and dorsal horn neuron
6) Confidence 0.75 Published 2004 Journal Brain Res. Section Abstract Doc Link 15033433 Disease Relevance 0.69 Pain Relevance 0.57
WIN55,212-3, the enantiomer of the active compound, also failed to suppress carrageenan-evoked Fos protein expression.
Gene_expression (expression) of Fos protein
7) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617970 Disease Relevance 0.79 Pain Relevance 1.14
A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Gene_expression (expression) of fos protein in spinal associated with pain, inflammation, analgesic and cannabinoid
8) Confidence 0.73 Published 2003 Journal Neuroscience Section Title Doc Link 12617970 Disease Relevance 0.79 Pain Relevance 1.56
We examined peripheral cannabinoid modulation of spinal Fos protein expression, a marker of neuronal activity, in a rat model of inflammation.
Gene_expression (expression) of Fos protein in neuronal associated with inflammation and cannabinoid
9) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617970 Disease Relevance 0.65 Pain Relevance 0.82
The suppressive effects of WIN55,212-2 (30 microg intraplantarly) on carrageenan-evoked Fos protein expression and pain behavior were blocked by local administration of either the CB(2) antagonist SR144528 (30 microg intraplantarly) or the CB(1) antagonist SR141716A (100 microg intraplantarly).
Gene_expression (expression) of Fos protein associated with pain and antagonist
10) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617970 Disease Relevance 0.91 Pain Relevance 1.29
In immunocytochemical studies, WIN55,212-2 suppressed the development of carrageenan-evoked Fos protein expression in the lumbar dorsal horn of the spinal cord relative to vehicle treatment.
Gene_expression (expression) of Fos protein in spinal cord associated with dorsal horn and spinal cord
11) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617970 Disease Relevance 0.90 Pain Relevance 1.18
AM1241 suppressed carrageenan-evoked Fos protein expression in the superficial and neck region of the dorsal horn but not in the nucleus proprius or the ventral horn.
Gene_expression (expression) of Fos protein in horn associated with dorsal horn
12) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 0.99 Pain Relevance 1.11
The same dose administered systemically or to the noninflamed contralateral paw failed to alter either carrageenan-evoked allodynia and hyperalgesia or carrageenan-evoked Fos protein expression, consistent with a peripheral site of action.
Gene_expression (expression) of Fos protein in paw associated with hyperalgesia and allodynia
13) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617970 Disease Relevance 0.94 Pain Relevance 1.22
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Gene_expression (expression) of fos protein in spinal associated with pain, inflammation, analgesic and cannabinoid
14) Confidence 0.73 Published 2003 Journal Neuroscience Section Title Doc Link 12809695 Disease Relevance 1.06 Pain Relevance 1.71
In immunocytochemical studies, AM1241 suppressed spinal Fos protein expression, a marker of neuronal activity, in the carrageenan model of inflammation.
Gene_expression (expression) of Fos protein in neuronal associated with inflammation
15) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 1.04 Pain Relevance 1.03
The suppression of carrageenan-evoked Fos protein expression induced by AM1241 was blocked by coadministration of SR144528 in all spinal laminae.
Gene_expression (expression) of Fos protein in spinal
16) Confidence 0.73 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 0.89 Pain Relevance 1.07
In urethan-anesthetized Wistar rats with cystitis, intravesical saline distension significantly (P </= 0.0005) increased the number of Fos-immunoreactive (IR) cells observed in the rostral lumbar (L1, 35 cells/section; L2, 27 cells/section) and caudal lumbosacral (L6, 120 cells/section; S1, 96 cells/section) spinal cord compared with control animals, but Fos protein expression in the L5 segment was not altered.
Gene_expression (expression) of Fos protein in spinal cord associated with cystitis and spinal cord
17) Confidence 0.72 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10749792 Disease Relevance 0.40 Pain Relevance 0.34
These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after cyclophosphamide (CYP)-induced bladder inflammation.
Spec (examined) Gene_expression (expression) of Fos protein in bladder associated with inflammation and spinal cord
18) Confidence 0.72 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10749792 Disease Relevance 0.25 Pain Relevance 0.17
Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis.
Gene_expression (expression) of Fos protein in spinal cord associated with qutenza, cystitis and spinal cord
19) Confidence 0.72 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 10749792 Disease Relevance 0.40 Pain Relevance 0.83
Using the retrograde transneuronal transport of pseudorabies virus central autonomic cardiomotor circuitry was identified and Fos protein expression was used for characterization of networks participating in cardiac pain perception, evaluation, and initiation of coping responses.
Gene_expression (expression) of Fos protein in autonomic associated with pain and pseudorabies
20) Confidence 0.70 Published 1999 Journal Eur J Morphol Section Abstract Doc Link 10477471 Disease Relevance 1.28 Pain Relevance 0.48

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