INT11855

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 12.22
Pain Relevance 14.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rl1) extracellular space (Il1rl1) extracellular region (Il1rl1)
plasma membrane (Il1rl1) intracellular (Il1rl1) molecular_function (Il1rl1)
Anatomy Link Frequency
spinal 8
spinal cord 4
neurons 4
TMJ 2
brain 2
Il1rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 28 100.00 Very High Very High Very High
Hyperalgesia 20 100.00 Very High Very High Very High
Eae 20 100.00 Very High Very High Very High
Dorsal horn 8 100.00 Very High Very High Very High
Kinase C 6 100.00 Very High Very High Very High
hyperexcitability 6 100.00 Very High Very High Very High
Dorsal horn neuron 6 100.00 Very High Very High Very High
Sciatic nerve 4 100.00 Very High Very High Very High
Thermal hyperalgesia 3 100.00 Very High Very High Very High
Spinal cord 15 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 23 100.00 Very High Very High Very High
Injury 8 100.00 Very High Very High Very High
INFLAMMATION 33 99.96 Very High Very High Very High
Pain 20 99.64 Very High Very High Very High
Urological Neuroanatomy 14 99.08 Very High Very High Very High
Pseudorabies 2 98.68 Very High Very High Very High
Cystitis 5 98.64 Very High Very High Very High
Temporomandibular Joint Syndrome 19 98.48 Very High Very High Very High
Nociception 28 98.42 Very High Very High Very High
Myocardial Infarction 14 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subarachnoid administration of adenosine (AD) or AD agonists promotes sleep and induces expression of Fos protein in VLPO neurons.
Positive_regulation (induces) of Gene_expression (expression) of Fos protein in neurons associated with adenocard and agonist
1) Confidence 0.69 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831851 Disease Relevance 0 Pain Relevance 0.42
Potentiated expression of FOS protein in the rat spinal cord following bilateral noxious cutaneous stimulation.
Positive_regulation (Potentiated) of Gene_expression (expression) of FOS protein in spinal cord associated with pain and spinal cord
2) Confidence 0.69 Published 1992 Journal Neuroscience Section Title Doc Link 1603331 Disease Relevance 0 Pain Relevance 0.23
Compared to cutaneous CFA injection, the injection of CFA into the TMJ produced a significantly stronger inflammation associated with a selective upregulation of preprodynorphin mRNA in the trigeminal spinal complex, an enhanced medullary dorsal horn hyperexcitability, and a greater trigeminal Fos protein expression, a marker of neuronal activation.
Positive_regulation (upregulation) of Gene_expression (expression) of Fos protein in neuronal associated with snapping jaw, inflammation, dorsal horn and hyperexcitability
3) Confidence 0.69 Published 2001 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 11455119 Disease Relevance 1.83 Pain Relevance 1.66
A modified conscious rat model of acute heart pain was employed for induction of cerebral Fos protein expression.
Positive_regulation (induction) of Gene_expression (expression) of Fos protein in heart associated with pain
4) Confidence 0.63 Published 1999 Journal Eur J Morphol Section Abstract Doc Link 10477471 Disease Relevance 1.44 Pain Relevance 0.56
Our results demonstrated that Fos protein expression in the spinal dorsal horn neurons at L5 segment ipsilateral and contralateral to CCI of the sciatic nerve was significantly greater than in sham rats from days 10 to 30 postoperatively (PO 10d to 30d), and was concentrated on the injury (ipsilateral) side.
Positive_regulation (concentrated) of Gene_expression (expression) of Fos protein in neurons associated with eae, injury, sciatic nerve and dorsal horn neuron
5) Confidence 0.48 Published 2004 Journal Brain Res. Section Abstract Doc Link 15033433 Disease Relevance 0.86 Pain Relevance 0.73
Using the retrograde transneuronal transport of pseudorabies virus central autonomic cardiomotor circuitry was identified and Fos protein expression was used for characterization of networks participating in cardiac pain perception, evaluation, and initiation of coping responses.
Positive_regulation (used) of Gene_expression (expression) of Fos protein in autonomic associated with pain and pseudorabies
6) Confidence 0.45 Published 1999 Journal Eur J Morphol Section Abstract Doc Link 10477471 Disease Relevance 1.29 Pain Relevance 0.48
The suppression of carrageenan-evoked Fos protein expression induced by AM1241 was blocked by coadministration of SR144528 in all spinal laminae.
Positive_regulation (induced) of Gene_expression (expression) of Fos protein in spinal
7) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 0.89 Pain Relevance 1.08
Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis.
Positive_regulation (induced) of Gene_expression (expression) of Fos protein in spinal cord associated with qutenza, cystitis and spinal cord
8) Confidence 0.43 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 10749792 Disease Relevance 0.40 Pain Relevance 0.83
The large reduction that was observed in SSS stimulation-evoked Fos protein expression following the administration of MK-801, taken together with electrophysiological data, indicates a role for glutamate in neurotransmission within the trigeminocervical complex.
Positive_regulation (stimulation-evoked) of Gene_expression (expression) of Fos protein in SSS associated with glutamate
9) Confidence 0.29 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430892 Disease Relevance 0.05 Pain Relevance 0.33
The expression of Fos protein induced by ACTH was also observed in rat brain.
Positive_regulation (induced) of Gene_expression (expression) of Fos protein in brain
10) Confidence 0.16 Published 1995 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 7652513 Disease Relevance 0 Pain Relevance 0.98
This anti-nociceptive effect was accompanied by an HU210-induced attenuation of the formalin-evoked increase in Fos protein expression in the caudal lateral PAG.
Positive_regulation (increase) of Gene_expression (expression) of Fos protein in PAG associated with nociception and periaqueductal grey
11) Confidence 0.14 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12941373 Disease Relevance 1.23 Pain Relevance 0.92
TMJ inflammation resulted in more robust changes in MDH nociceptive neurons as compared with PO inflammation, consistent with previous studies of increased inflammation, increased MDH Fos-protein expression, and increased MDH preprodynorphin mRNA expression in this deep tissue orofacial model of pain and hyperalgesia.
Positive_regulation (increased) of Gene_expression (expression) of MDH Fos-protein in TMJ associated with nociception, pain, hyperalgesia, snapping jaw, inflammation and deep tissue
12) Confidence 0.13 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10482744 Disease Relevance 1.52 Pain Relevance 1.36
Capsaicin-evoked Fos protein expression was increased in the superficial and neck regions of the dorsal horn of adult P0-CFA-treated rats relative to P0-vehicle-treated rats.
Positive_regulation (increased) of Gene_expression (expression) of Fos protein in dorsal horn associated with qutenza and dorsal horn
13) Confidence 0.12 Published 2005 Journal J Pain Section Abstract Doc Link 16326368 Disease Relevance 0.66 Pain Relevance 0.96
Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat.
Positive_regulation (Involvement) of Gene_expression (expression) of fos protein in spinal associated with kinase c and thermal hyperalgesia
14) Confidence 0.10 Published 2006 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 16730785 Disease Relevance 0.44 Pain Relevance 0.82
In contrast, Chritin et al. [35] reported that amphetamine caused up-regulated Fos protein expression on both sides of hemiparkinsonian rats, with the increases being of smaller magnitude on the DA-denervated side.
Positive_regulation (caused) of Gene_expression (expression) of Fos protein associated with dopamine
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.68
In contrast, Chritin et al. [35] reported that amphetamine caused up-regulated Fos protein expression on both sides of hemiparkinsonian rats, with the increases being of smaller magnitude on the DA-denervated side.
Positive_regulation (regulated) of Gene_expression (expression) of Fos protein associated with dopamine
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.68
These results are very similar to previous data showing that FOS protein expression increases in the mPFC following extinction training (Santini et al., 2004), and recent results examining CREB activity in the mPFC following extinction training of different lengths (Mamiya et al., 2009).
Positive_regulation (increases) of Gene_expression (expression) of FOS protein
17) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.06 Pain Relevance 0.23
Injections into the paw of sub-inflammatory doses of PAR2 agonists in rats and mice induced a prolonged thermal and mechanical hyperalgesia and elevated spinal Fos protein expression.
Positive_regulation (induced) of Gene_expression (expression) of Fos protein in spinal associated with hyperalgesia, inflammation and agonist
18) Confidence 0.02 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.71 Pain Relevance 0.69
As reported in the study by Tani et al. [24], selective destruction of dentate granule cells by colchicine resulted in a marked increase in methamphetamine-induced Fos protein expression, a marker of neuronal activity, not only in the nucleus accumbens but also in other brain regions such as the dorsal striatum.
Positive_regulation (induced) of Gene_expression (expression) of Fos protein in granule cells associated with nucleus accumbens
19) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2572851 Disease Relevance 0.12 Pain Relevance 0.26
Injections into the paw of sub-inflammatory doses of PAR2 agonists in rats and mice induced a prolonged thermal and mechanical hyperalgesia and elevated spinal Fos protein expression.
Positive_regulation (elevated) of Gene_expression (expression) of Fos protein in spinal associated with hyperalgesia, inflammation and agonist
20) Confidence 0.01 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.71 Pain Relevance 0.68

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