INT118558

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.98
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xbp1) DNA binding (Xbp1)
Anatomy Link Frequency
SH-SY5Y 3
acinar cells 1
Xbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 10 99.36 Very High Very High Very High
cINOD 8 96.08 Very High Very High Very High
diclofenac 1 93.52 High High
Hippocampus 96 71.12 Quite High
Inflammation 90 54.32 Quite High
Central nervous system 10 45.76 Quite Low
depression 20 33.40 Quite Low
Inflammatory response 40 5.00 Very Low Very Low Very Low
gABA 26 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 281 100.00 Very High Very High Very High
Shock 14 100.00 Very High Very High Very High
Aging 202 99.44 Very High Very High Very High
Apoptosis 95 98.16 Very High Very High Very High
Sprains And Strains 251 97.86 Very High Very High Very High
Death 164 92.28 High High
Disease 37 90.80 High High
Atherosclerosis 106 89.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 83.92 Quite High
INFLAMMATION 128 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of Xbp1-s (spliced form) were normalized to Xbp1-t (total) levels.
Gene_expression (Levels) of Xbp1
1) Confidence 0.72 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0 Pain Relevance 0
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Gene_expression (expression) of Xbp1 associated with stress, aging, shock and sprains and strains
2) Confidence 0.64 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.81 Pain Relevance 0.06
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Gene_expression (expression) of X-box binding protein 1 associated with stress, aging, shock and sprains and strains
3) Confidence 0.64 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.80 Pain Relevance 0.06
At P14-19, the average fold difference (± s.e.m., sample size) in mutants as compared to wild-type littermates was as follows: BiP, 1.21 (± 0.17, n = 7); Chop, 0.93 (± 0.22, n = 14); Xbp1-s, 1.15 (± 0.17, n = 11).
Gene_expression (follows) of Xbp1
4) Confidence 0.62 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.67 Pain Relevance 0
Finally, in order to assess the level of ER-stress in acinar cells, the expression of the principal regulatory components and markers of ER-stress including BiP, Chop, and the spliced form of Xbp1 (Xbp1-s) were examined.
Gene_expression (expression) of Xbp1 in acinar cells associated with stress
5) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.56 Pain Relevance 0
Three factors that positively regulate CHOP expression (ATF6, ATF4 and XBP-1) were activated and/or induced by indomethacin.
Gene_expression (expression) of XBP-1
6) Confidence 0.40 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15131590 Disease Relevance 0.89 Pain Relevance 0.68
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Gene_expression (production) of X-box binding protein 1 associated with chemokine and shock
7) Confidence 0.37 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.42 Pain Relevance 0.05
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Gene_expression (production) of XBP1 associated with chemokine and shock
8) Confidence 0.37 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.42 Pain Relevance 0.05
Consistent with previous results, this activation can be enhanced by co-transfection of the transcription factor XBP-1.
Gene_expression (transfection) of XBP-1
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.31 Pain Relevance 0
To test this idea, we co-transfected SH-SY5Y cells with XBP-1 expression plasmid along with the WFS1 reporter plasmid or the control plasmid with or without valproate treatment.
Gene_expression (transfected) of XBP-1 in SH-SY5Y
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.11 Pain Relevance 0
We therefore considered the possibility that the addition of valproate to XBP-1 expression can enhance luciferease activity.
Gene_expression (expression) of XBP-1
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.17 Pain Relevance 0
To test this idea, we measured mRNA expression levels of common ER stress response genes, GRP94, GRP78, total and spliced XBP-1, and AATF by real-time PCR.
Gene_expression (expression) of XBP-1 associated with stress
12) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.71 Pain Relevance 0
SH-SY5Y cells were transfected with a reporter plasmid containing 500 bases of the WFS1 promoter driving the luciferase gene (pGL3-WFS1-long), a control reporter plasmid containing only 60 bases of the WFS1 promoter (pGL3-WFS1-short), or control plasmid (pGL3) plus XBP-1 expression plasmid or control plasmid using Lipofectamine™ 2000 (Invitrogen, Carlsbad, CA). 48 hrs post-transfection, the cells were treated with two different concentrations of valproate, 50 µg/ml and 200 µg/ml, for 6 hr and then lysed using a Luciferase Assay System kit (Promega, Madison, WI).
Gene_expression (expression) of XBP-1 in SH-SY5Y
13) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
To test this idea, we co-transfected SH-SY5Y cells with XBP-1 expression plasmid along with the WFS1 reporter plasmid or the control plasmid with or without valproate treatment.
Gene_expression (expression) of XBP-1 in SH-SY5Y
14) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.11 Pain Relevance 0

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