INT118559

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 15.66
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
retina 1
apoptotic cell 1
podocytes 1
body 1
growth plate 1
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 11 99.96 Very High Very High Very High
Inflammation 118 99.38 Very High Very High Very High
depression 25 98.28 Very High Very High Very High
cytokine 18 93.72 High High
diclofenac 1 82.32 Quite High
Central nervous system 45 75.40 Quite High
aspirin 3 72.80 Quite High
Hippocampus 48 68.00 Quite High
metalloproteinase 10 42.80 Quite Low
Inflammatory response 17 22.40 Low Low
Disease Link Frequency Relevance Heat
Stress 560 100.00 Very High Very High Very High
Shock 10 100.00 Very High Very High Very High
Death 243 99.58 Very High Very High Very High
INFLAMMATION 134 99.38 Very High Very High Very High
Apoptosis 109 99.36 Very High Very High Very High
Disease 82 99.36 Very High Very High Very High
Myositis 84 99.32 Very High Very High Very High
Aging 104 98.70 Very High Very High Very High
Malaria 135 98.68 Very High Very High Very High
Depression 25 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This anti-inflammatory potential was correlated with induction of 78-kDa glucose-regulated protein (GRP78), a marker of unfolded protein response (UPR).
Positive_regulation (induction) of GRP78 associated with inflammation
1) Confidence 0.61 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.40 Pain Relevance 0.20
This anti-inflammatory potential was correlated with induction of 78-kDa glucose-regulated protein (GRP78), a marker of unfolded protein response (UPR).
Positive_regulation (induction) of glucose-regulated protein associated with inflammation
2) Confidence 0.53 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.34 Pain Relevance 0.20
As shown in figure 2, panel A, no induction of the ER stress genes BiP, CHOP, calreticulin or Grp58 was observed in FrCasE-infected microglial cultures when compared with mock or Fr57E-infected cells.
Neg (no) Positive_regulation (induction) of BiP associated with stress
3) Confidence 0.47 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.66 Pain Relevance 0.07
Using immunoblots, as shown in Figure 5C, we found that BiP was significantly increased at 12 h after the NMDA injection, and that the increase persisted for the remainder of the 72 h observation period.
Positive_regulation (increased) of BiP
4) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.45 Pain Relevance 0
On the other hand, we found that staurosporine, which mediates mitochondrial dysfunctions resulting in apoptotic cell death, did not induce any increases in BiP and CHOP proteins in RGC-5 [unpublished data].
Neg (not) Positive_regulation (increases) of BiP in apoptotic cell associated with apoptosis and death
5) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.16 Pain Relevance 0
Increases in GRP78/BiP and CHOP in mouse retina after NMDA injection
Positive_regulation (Increases) of GRP78/BiP in retina
6) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.51 Pain Relevance 0
These results suggested that indomethacin suppressed the response of podocytes to TNF-alpha via UPR and that UPR-triggered induction of GRP78 and degradation of TRAF2 may be responsible, at least in part, for the suppressive effect of indomethacin.
Positive_regulation (induction) of GRP78 in podocytes
7) Confidence 0.44 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.18 Pain Relevance 0.16
Exposure of cells to indomethacin, a commonly used NSAID, induced GRP78 as well as CHOP, a transcription factor involved in apoptosis.
Positive_regulation (induced) of GRP78 associated with cinod and apoptosis
8) Confidence 0.41 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15131590 Disease Relevance 0.91 Pain Relevance 0.64
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Positive_regulation (increased) of Hspa5 associated with stress, aging, shock and sprains and strains
9) Confidence 0.40 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.75 Pain Relevance 0.06
Nonetheless, it should be borne in mind that lack of GRP78 induction does not necessarily imply that malaria elicited no ER stress.
Positive_regulation (induction) of GRP78 associated with stress and malaria
10) Confidence 0.40 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.27 Pain Relevance 0
Nichols and Kirby [42] also noted that pyrazole produced a greater increase in GRP78 protein in G6PD-deficient mice than in wild type mice, and that menadione did not alter GRP78 levels either in wild type or in G6PD-deficient animals.
Positive_regulation (increase) of GRP78 protein
11) Confidence 0.40 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.84 Pain Relevance 0
More recently, we showed that TUDCA reduces BiP induction in TTR mice [12].
Positive_regulation (induction) of BiP
12) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.59 Pain Relevance 0
On the basis of our previous findings in the mutant cartilage growth plate, where BiP was significantly upregulated and Bcl-2 was downregulated (20) owing to the expression of mutant Comp T585M, we considered the possibility that the expression of mutant Comp T585M was eliciting an rER/cell stress response in tenocytes that might eventually be causing increased cell death.
Positive_regulation (upregulated) of BiP in growth plate associated with stress and death
13) Confidence 0.35 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.70 Pain Relevance 0
The ability of TUDCA to abolish ER stress was previously observed and reduction of BiP induction and caspase 12 activation were reported [15]; TUDCA is also able to protect against oxidative stress in tissues damaged by TTR deposition and thus, TUDCA can act at different levels, affecting TTR extracellular deposition.
Positive_regulation (induction) of BiP associated with stress
14) Confidence 0.35 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.68 Pain Relevance 0
In the present study, we found that tunicamycin induced the ER stress-associated proteins BiP, p-eIF2?
Positive_regulation (induced) of BiP associated with stress
15) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.99 Pain Relevance 0
At P14-19, the average fold difference (± s.e.m., sample size) in mutants as compared to wild-type littermates was as follows: BiP, 1.21 (± 0.17, n = 7); Chop, 0.93 (± 0.22, n = 14); Xbp1-s, 1.15 (± 0.17, n = 11).
Positive_regulation (follows) of BiP
16) Confidence 0.30 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.65 Pain Relevance 0
No induction of GRP78 was found in P.berghei-infected mice, a finding that suggests that CYP2a5 up-modulation may occur in the absence of ER stress.
Neg (No) Positive_regulation (induction) of GRP78 associated with stress
17) Confidence 0.27 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.81 Pain Relevance 0.05
Except for sporadic inclusion-body myositis, where the ER chaperones calnexin, calreticulin, Grp78, Grp94 and ERp72 are upregulated and colocalize with intracellular aggregates [11,12], the present knowledge about changes in ER chaperone level and distribution among myofibers of myositis patients is far from complete.
Positive_regulation (upregulated) of Grp78 in body associated with myositis
18) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.68 Pain Relevance 0
BiP and CHOP were increased at 12 h after NMDA injection, and the increases persisted for the remainder of the 72 h observation period.


Positive_regulation (increased) of BiP
19) Confidence 0.14 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2652022 Disease Relevance 0.97 Pain Relevance 0
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Positive_regulation (increased) of BiP
20) Confidence 0.13 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0

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