INT118565

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 23.62
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddit3) cell cycle (Ddit3) DNA binding (Ddit3)
transcription factor binding (Ddit3) cytoplasm (Ddit3)
Anatomy Link Frequency
microglia 8
arm 3
retina 2
brain 1
apoptotic cell 1
Ddit3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dextromethorphan 14 99.60 Very High Very High Very High
diclofenac 14 98.88 Very High Very High Very High
nMDA receptor antagonist 12 97.84 Very High Very High Very High
Paracetamol 8 96.64 Very High Very High Very High
Central nervous system 366 96.60 Very High Very High Very High
chemokine 2 96.16 Very High Very High Very High
cINOD 22 95.28 Very High Very High Very High
Inflammation 109 95.16 Very High Very High Very High
cytokine 23 95.04 Very High Very High Very High
aspirin 1 81.92 Quite High
Disease Link Frequency Relevance Heat
Stress 969 100.00 Very High Very High Very High
Apoptosis 400 100.00 Very High Very High Very High
Death 336 100.00 Very High Very High Very High
Cancer 53 99.82 Very High Very High Very High
Infection 713 98.96 Very High Very High Very High
Diffuse Large B-cell Lymphoma 15 98.28 Very High Very High Very High
Repression 5 98.00 Very High Very High Very High
Adhesions 1 97.84 Very High Very High Very High
Disease 246 97.08 Very High Very High Very High
Diabetes Mellitus 147 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblotting for CHOP (GADD 153) protein expression was performed on cellular extracts taken from microglia and mixed glial cultures (1°CNS) after treatment for 24 hours with either 1 ?
Gene_expression (expression) of GADD 153 in microglia associated with central nervous system
1) Confidence 0.75 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0.05
Three factors that positively regulate CHOP expression (ATF6, ATF4 and XBP-1) were activated and/or induced by indomethacin.
Gene_expression (expression) of CHOP
2) Confidence 0.69 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15131590 Disease Relevance 0.89 Pain Relevance 0.68
The expression of the CHOP gene reportedly increases in the rat retina after intravitreal injection of NMDA [29].
Gene_expression (expression) of CHOP gene in retina
3) Confidence 0.63 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.02 Pain Relevance 0.08
Furthermore, Zinszner et al. [20] noted that in mice, a single sublethal intraperitoneal injection of tunicamycin (1 mg/kg) induces CHOP expression and subsequent severe histological damage with an increase in TUNEL-positive cells, and a characteristic transient renal insufficiency.
Gene_expression (expression) of CHOP associated with renal insufficiency
4) Confidence 0.63 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.76 Pain Relevance 0.03
was increased concomitantly with the increases in the expression of BiP and CHOP proteins, even through p-eIF2?
Gene_expression (expression) of CHOP
5) Confidence 0.63 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.89 Pain Relevance 0
Furthermore, indomethacin-induced apoptosis was suppressed in cultured guinea-pig gastric mucosal cells by expression of the dominant-negative form of CHOP, or in peritoneal macrophages from CHOP-deficient mice.
Gene_expression (expression) of CHOP in peritoneal macrophages associated with apoptosis
6) Confidence 0.60 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15131590 Disease Relevance 0.80 Pain Relevance 0.62
Transcriptional activation and elevated expression of GADD153/CHOP, an ER stress-responsive proapoptotic transcription factor, was observed upon AAP addition.
Gene_expression (expression) of GADD153 associated with stress and paracetamol
7) Confidence 0.58 Published 2007 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 17207453 Disease Relevance 0.42 Pain Relevance 0.58
The levels of the JNK-regulated proapoptotic transcription factor C/EBP homologous protein (CHOP) were also increased after DCF.
Gene_expression (levels) of CHOP associated with diclofenac
8) Confidence 0.58 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20501447 Disease Relevance 0.85 Pain Relevance 0.75
To evaluate whether NV virus infection of microglia induced ER stress only in the context of the brain, microglial enriched fractions derived from FrCasE-, F43- and mock-infected mice (14 dpi) were examined by Taqman real-time quantitative RT-PCR to assess BiP and CHOP RNA expression levels.
Gene_expression (expression) of CHOP RNA in brain associated with stress and infection
9) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.43 Pain Relevance 0
While it is possible that microglia tin situ are susceptible to NV-induced ER stress, preliminary experiments by Dimcheff and Portis have not observed CHOP expression in association with microglia in FrCasE-infected brains (personal communication).
Gene_expression (expression) of CHOP in microglia associated with stress
10) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.60 Pain Relevance 0.03
Comparison of CHOP expression between isolated microglia and mixed glial cultures showed that constitutive CHOP expression levels were much higher in the mixed glia, and could be further elevated by thapsigargin treatment.
Gene_expression (expression) of CHOP in microglia
11) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.66 Pain Relevance 0
As with the microglia, no differences in CHOP expression was noted between mock-, NN- and NV-infected mixed glial cultures (not shown).
Gene_expression (expression) of CHOP in microglia
12) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.69 Pain Relevance 0
Both FrCasE- and Fr57E-infection of microglia resulted in a significant decrease in CHOP message expression, however, the importance of this decrease is not clear.
Gene_expression (expression) of CHOP in microglia associated with infection
13) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.65 Pain Relevance 0.06
Given that we observed higher basal levels of CHOP expression in the mixed glial cultures compared to microglia, it is likely that non-microglial cells are responsible for CNS ER stress.
Gene_expression (expression) of CHOP in microglia associated with stress and central nervous system
14) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.73 Pain Relevance 0.05
Immunoblotting for CHOP (GADD 153) protein expression was performed on cellular extracts taken from microglia and mixed glial cultures (1°CNS) after treatment for 24 hours with either 1 ?
Gene_expression (expression) of CHOP in microglia associated with central nervous system
15) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0.05
Comparison of CHOP expression between isolated microglia and mixed glial cultures showed that constitutive CHOP expression levels were much higher in the mixed glia, and could be further elevated by thapsigargin treatment.
Gene_expression (expression) of CHOP in microglia
16) Confidence 0.55 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.61 Pain Relevance 0
On the other hand, we found that staurosporine, which mediates mitochondrial dysfunctions resulting in apoptotic cell death, did not induce any increases in BiP and CHOP proteins in RGC-5 [unpublished data].
Gene_expression (proteins) of CHOP in apoptotic cell associated with apoptosis and death
17) Confidence 0.54 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.16 Pain Relevance 0
Furthermore, Awai et al. [30] found that treatment with MK-801, an NMDA receptor antagonist, inhibited the increases in CHOP mRNA and protein in the mouse retina that are observed after intravitreal injection of NMDA, and moreover that CHOP-deficient mice were resistant to NMDA-induced retinal damage.
Gene_expression (injection) of CHOP in retina associated with nmda receptor antagonist
18) Confidence 0.54 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.06 Pain Relevance 0.05
Finally, in order to assess the level of ER-stress in acinar cells, the expression of the principal regulatory components and markers of ER-stress including BiP, Chop, and the spliced form of Xbp1 (Xbp1-s) were examined.
Gene_expression (expression) of Chop in acinar cells associated with stress
19) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.56 Pain Relevance 0
At P14-19, the average fold difference (± s.e.m., sample size) in mutants as compared to wild-type littermates was as follows: BiP, 1.21 (± 0.17, n = 7); Chop, 0.93 (± 0.22, n = 14); Xbp1-s, 1.15 (± 0.17, n = 11).
Gene_expression (follows) of Chop
20) Confidence 0.51 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.66 Pain Relevance 0

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