INT118575

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 3.35
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6PD) small molecule metabolic process (G6PD) oxidoreductase activity (G6PD)
carbohydrate metabolic process (G6PD) lipid metabolic process (G6PD) cytoplasm (G6PD)
Anatomy Link Frequency
leg 2
muscle 1
G6PD (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 84.48 Quite High
Osteoarthritis 1 66.24 Quite High
Pain 19 64.96 Quite High
cytokine 3 25.00 Low Low
imagery 21 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 1 100.00 Very High Very High Very High
Hemolysis 1 99.98 Very High Very High Very High
Disease 13 95.44 Very High Very High Very High
Fever 4 95.12 Very High Very High Very High
Malaria 62 93.76 High High
Convulsion 3 92.44 High High
Vomiting 10 91.92 High High
Infection 34 90.92 High High
Hemolytic Anemia 8 89.76 High High
Body Weight 8 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With duration of approximately 3 hours for the PCR amplification step followed by 4 hours for the SSOP-ELISA detection, 90 samples can easily be screened for both haemoglobin and G6PD genotypes or 180 samples for either haemoglobin or G6PD, during one day.
Positive_regulation (screened) of G6PD
1) Confidence 0.50 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0.05 Pain Relevance 0
With duration of approximately 3 hours for the PCR amplification step followed by 4 hours for the SSOP-ELISA detection, 90 samples can easily be screened for both haemoglobin and G6PD genotypes or 180 samples for either haemoglobin or G6PD, during one day.
Positive_regulation (screened) of G6PD
2) Confidence 0.50 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0 Pain Relevance 0
The PCR conditions for both the G6PD and HbB gene were 15 minutes of incubation at 94°C, followed by 45 amplification cycles of denaturation at 94°C for 30 seconds, annealing at 60°C for 30 seconds and elongation at 72°C for 90 seconds (60 seconds for the HbB gene), before the final elongation at 72°C for 10 minutes.
Positive_regulation (conditions) of G6PD
3) Confidence 0.50 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0 Pain Relevance 0
Furthermore, the therapy increased the levels of alpha atrial natriuretic polypeptide (alpha ANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level.
Positive_regulation (increased) of glucose-6-phosphate dehydrogenase associated with natriuresis
4) Confidence 0.45 Published 2004 Journal J. Radiat. Res. Section Abstract Doc Link 15133294 Disease Relevance 0.33 Pain Relevance 0.10
Children were screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency before randomisation (the G6PD test took about 1hour).
Positive_regulation (screened) of G6PD
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2430614 Disease Relevance 0.99 Pain Relevance 0
Children were screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency before randomisation (the G6PD test took about 1hour).
Positive_regulation (screened) of glucose-6-phosphate dehydrogenase
6) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2430614 Disease Relevance 0.99 Pain Relevance 0
A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency.
Positive_regulation (trigger) of glucose-6-phosphate dehydrogenase associated with hemolysis
7) Confidence 0.34 Published 2009 Journal Saudi Med J Section Title Doc Link 19198723 Disease Relevance 0.85 Pain Relevance 0.08
Thus, the clear differences in exercise-induced muscle glucose-6-phosphate and muscle glucose responses in the normal and the low muscle glycogen muscles in the high FFA trial were not associated with differences in PDH regulation, and despite similar muscle glucose-6-phosphate and muscle glucose levels in the normal glycogen leg in the two trials, PDHa activity was higher in the low FFA trial than in the high FFA trial.
Positive_regulation (induced) of glucose-6-phosphate in muscle
8) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Hence, accumulation of glycolytic intermediates may depend on how well glycolytic flux and PDH activity match, and the lack of accumulation of intermediates in the low leg in both trials may reflect a balanced glycolytic flux and PDH activity, whereas glycolytic flux may have exceeded PDH activity in the CON leg, leading to accumulation of glucose-6-phosphate.
Positive_regulation (accumulation) of glucose-6-phosphate in leg
9) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
No changes were observed over time in muscle glucose-6-phosphate concentration in the LOW leg in either trial, whereas the glucose-6-phosphate concentration in the CON leg was increased (P ?
Positive_regulation (increased) of glucose-6-phosphate in leg
10) Confidence 0.04 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
This depletion results in the inhibition of glycolysis and subsequent stimulation of the NADP+-dependent hexose monophosphate shunt (HMS) owing to accumulation of glucose-6-phosphate.
Positive_regulation (accumulation) of glucose-6-phosphate
11) Confidence 0.01 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.14 Pain Relevance 0

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