INT118583

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.75
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF1) nucleoplasm (IRF1) nucleus (IRF1)
Anatomy Link Frequency
MAR 3
MCF7 1
MAR 1
MAL 1
IRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 42 99.58 Very High Very High Very High
Glutamate 22 99.26 Very High Very High Very High
Inflammation 74 91.84 High High
cytokine 51 88.12 High High
metalloproteinase 5 85.32 High High
anesthesia 2 79.08 Quite High
Opioid 2 67.92 Quite High
antagonist 4 67.36 Quite High
agonist 54 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 26 99.58 Very High Very High Very High
Malignant Neoplastic Disease 2 93.88 High High
INFLAMMATION 86 91.84 High High
Neck Pain 4 88.56 High High
Necrosis 6 82.24 Quite High
Cancer 9 81.88 Quite High
Myalgia 10 81.36 Quite High
Skin Cancer 2 70.72 Quite High
Cirrhosis 61 68.92 Quite High
Congenital Anomalies 2 67.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EMG activity in MAL and MAR was increased in the head back position compared to head rest and head right positions, whereas EMG activity in SCM and SP was progressively increased as the head was moved from rest position to head back to head right positions.
Positive_regulation (increased) of MAR in MAR
1) Confidence 0.68 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.40 Pain Relevance 0.59
Glutamate-evoked MAR pain was associated with increases in EMG activity in MAR, SCM and SP at rest but not in the head back or head right positions.
Positive_regulation (increases) of MAR in MAR associated with pain and glutamate
2) Confidence 0.59 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.63 Pain Relevance 0.90
Decreases in jaw clench-related EMG activity were observed in MAL, MAR and SCM muscles only during glutamate-evoked MAR pain.
Positive_regulation (observed) of MAR in MAR associated with pain and glutamate
3) Confidence 0.43 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.67 Pain Relevance 0.95
RESULTS: Pain evoked by MAR or SP glutamate injections was associated with a significant increase in the stretch reflex amplitude recorded in both MAR and SCM.
Positive_regulation (increase) of MAR in MAR
4) Confidence 0.41 Published 2004 Journal Clin Neurophysiol Section Body Doc Link 15134695 Disease Relevance 0.07 Pain Relevance 0
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
Positive_regulation (increase) of interferon regulatory factor-1
5) Confidence 0.36 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.49 Pain Relevance 0.25
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
Positive_regulation (increase) of IRF-1
6) Confidence 0.36 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.49 Pain Relevance 0.25
EMG activity in MAL and MAR was increased in the head back position compared to head rest and head right positions, whereas EMG activity in SCM and SP was progressively increased as the head was moved from rest position to head back to head right positions.
Positive_regulation (increased) of MAR in MAL
7) Confidence 0.23 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.40 Pain Relevance 0.59
Stimulation of mAR by the non-permeable testosterone-BSA conjugate resulted in early actin reorganization documented by quantitative measurements of actin dynamics and morphological analysis of microfilament organization.
Positive_regulation (Stimulation) of mAR
8) Confidence 0.17 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.24 Pain Relevance 0.10
Here we report that this pathway operates in MCF7 cells upon activation of membrane androgen receptors (mAR).
Positive_regulation (activation) of mAR in MCF7
9) Confidence 0.16 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.24 Pain Relevance 0.10
and IFN-responsive genes [13,27], whereas IRF1 is activated via MyD88-dependent pathways.
Positive_regulation (activated) of IRF1
10) Confidence 0.13 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.13 Pain Relevance 0.17

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