INT118585

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.47
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (PNN) nucleolus (PNN) structural molecule activity (PNN)
plasma membrane (PNN) nucleus (PNN) DNA binding (PNN)
Anatomy Link Frequency
blood 1
PNN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 24 95.24 Very High Very High Very High
antagonist 5 95.08 Very High Very High Very High
cINOD 2 93.92 High High
withdrawal 14 85.68 High High
Bioavailability 9 67.48 Quite High
agonist 3 63.92 Quite High
nud 15 45.76 Quite Low
alcohol 1 32.00 Quite Low
depression 5 28.56 Quite Low
headache 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperkalemia 6 99.76 Very High Very High Very High
Premenstrual Syndrome 119 99.34 Very High Very High Very High
Hypertension 7 99.04 Very High Very High Very High
Acne 68 98.80 Very High Very High Very High
Hypotension 1 97.12 Very High Very High Very High
Reprotox - General 1 16 95.24 Very High Very High Very High
INFLAMMATION 1 93.72 High High
Diabetes Mellitus 1 92.36 High High
Polycystic Ovary Syndrome 12 90.88 High High
Body Weight 9 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For postmenopausal women, a combination of DRSP with estradiol has been developed with the expectation that the slight blood pressure lowering and weight reducing effects will minimize cardiovascular morbidity in patients needing hormone treatment because of hot flushes and other climacteric symptoms.
DRSP Binding (combination) of in blood associated with hypotension
1) Confidence 0.25 Published 2004 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 15134826 Disease Relevance 0.61 Pain Relevance 0.16
DRSP is highly bound to serum metabolites (approximately 97%) but does not bind to sex hormone binding globulin (SHBG).
DRSP Binding (bound) of
2) Confidence 0.19 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.06 Pain Relevance 0.09
In addition, E2/DRSP was not associated with hyperkalaemia (potassium > or =5.5 meq/L) irrespective of concomitant use of ACE inhibitors, angiotensin II receptor antagonists or non-steroidal anti-inflammatory drugs, and co-morbid diabetes mellitus.
DRSP Binding (associated) of associated with inflammation, hyperkalemia, diabetes mellitus, antagonist and cinod
3) Confidence 0.16 Published 2006 Journal Maturitas Section Abstract Doc Link 16949774 Disease Relevance 0.71 Pain Relevance 0.14
The symptoms of PMDD are statistically significantly improved with the use of 3 mg DRSP/20 ?
DRSP Binding (improved) of associated with premenstrual syndrome
4) Confidence 0.15 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.88 Pain Relevance 0.03
DRSP is highly bound to serum metabolites (approximately 97%) but does not bind to sex hormone binding globulin (SHBG).
DRSP Neg (not) Binding (bind) of
5) Confidence 0.14 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.07 Pain Relevance 0.09
Subjects were evaluated with the DRSP, Q-LES-Q, the CGI-I, and PMTS.
DRSP Binding (evaluated) of
6) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971718 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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