INT118589

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 3.35
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
OFC 2
gonadal 1
amygdala 1
OFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 13 100.00 Very High Very High Very High
drug abuse 4 99.98 Very High Very High Very High
Anterior cingulate cortex 406 99.92 Very High Very High Very High
Lamotrigine 9 99.76 Very High Very High Very High
Catecholamine 4 99.56 Very High Very High Very High
Pain 238 98.46 Very High Very High Very High
Morphine 7 96.20 Very High Very High Very High
Dopamine 30 95.08 Very High Very High Very High
Nucleus accumbens 14 94.96 High High
depression 23 93.28 High High
Disease Link Frequency Relevance Heat
Drug Dependence 4 99.98 Very High Very High Very High
Depression 23 99.60 Very High Very High Very High
Anxiety Disorder 89 98.64 Very High Very High Very High
Pain 155 98.46 Very High Very High Very High
Aggression 112 97.96 Very High Very High Very High
Cognitive Disorder 53 97.52 Very High Very High Very High
Weight Gain 14 93.52 High High
Manic Depressive Disorder 59 93.28 High High
Dyslipidemia /

Combined Dyslipidemia

3 92.48 High High
Stress 23 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differential response of the OFC and mPFC to drugs is paralleled by an areal-dependent effect of gonadal hormones on these regions as well: males have greater dendritic arborization in the mPFC whereas females have a greater arborization in the OFC.
Regulation (response) of OFC in gonadal
1) Confidence 0.23 Published 2004 Journal Brain Cogn Section Abstract Doc Link 15134846 Disease Relevance 0.34 Pain Relevance 0.18
Statistically, the efficacy of OFC was not significantly different from that of olanzapine, but inspection of the 95% CI showed a trend in favor of a possible superiority of OFC.
Regulation (efficacy) of OFC
2) Confidence 0.23 Published 2009 Journal J Clin Psychiatry Section Body Doc Link 19906346 Disease Relevance 0 Pain Relevance 0
In addition, it is yet unclear whether drug abuse affects the orbitofrontal cortex (OFC) and dorsolateral PFC (DLPFC)--the two most important subregions of the PFC--in similar ways or not.
Spec (whether) Regulation (affects) of OFC in OFC associated with drug abuse
3) Confidence 0.20 Published 2005 Journal Brain Res. Section Abstract Doc Link 16054602 Disease Relevance 0.36 Pain Relevance 0.47
Another study recently demonstrated that the appraisal of others' pain is mediated by brain structures involved in stimulus evaluation and emotion regulation (such as the medial orbitofrontal cortex OFC and the right lateral prefrontal cortex [24]).
Regulation (regulation) of OFC in cortex associated with pain
4) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2144768 Disease Relevance 0.36 Pain Relevance 0.26
The same OFC lesion affected performance on this task as well as both fear and aggression levels, suggesting that they may share a common neuroanatomical basis.
Regulation (affected) of OFC associated with aggression and anxiety disorder
5) Confidence 0.13 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.56 Pain Relevance 0
Here we report the effect of circumscribed excitotoxic lesions of either OFC or ACC on ethological, unconditioned tests of emotion and social behaviour in the Lister hooded rat.
Regulation (effect) of OFC
6) Confidence 0.13 Published 2007 Journal The European Journal of Neuroscience Section Abstract Doc Link PMC2228395 Disease Relevance 0.16 Pain Relevance 0.05
Moreover, unlike OFC lesions, the representation of expected outcomes in the delay-based decision-making task was not affected by ACC lesions (Rudebeck et al., 2006b).
Neg (not) Regulation (affected) of OFC associated with anterior cingulate cortex
7) Confidence 0.13 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.24 Pain Relevance 0.42
The study combined the results of two successive replications, which compared the effects of OFC, ACC and sham lesions.
Regulation (effects) of OFC associated with anterior cingulate cortex
8) Confidence 0.08 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.09 Pain Relevance 0.30
In this study treatment differences in illness severity, depressive symptoms and manic symptoms favored OFC over lamotrigine that reached statistical significance as early as week 1.
Regulation (favored) of OFC associated with depression and lamotrigine
9) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656294 Disease Relevance 0.89 Pain Relevance 0.59
As controls, 11 patients with both luteal phase defect and high CL-RI (?
Regulation (controls) of CL-RI
10) Confidence 0.02 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0.25 Pain Relevance 0
Receiver operating characteristic curve (ROC) analysis was performed to determine the cutoff value of the CL-RI providing the best value of the sensitivity and the specificity for determination of normal luteal function and luteal phase defect.
Spec (determine) Regulation (value) of CL-RI
11) Confidence 0.01 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0 Pain Relevance 0
Similarly, catecholamine functioning was also unaffected in the amygdala and OFC.
Neg (unaffected) Regulation (unaffected) of OFC in amygdala associated with catecholamine and amygdala
12) Confidence 0.01 Published 2010 Journal Neuroscience Section Body Doc Link PMC2930211 Disease Relevance 0 Pain Relevance 0.69
Interestingly, in patients with multiple corpora lutea, CL-RI did not vary much among the individual corpora lutea, which suggests that CL-RI is influenced by endocrine factors.
Regulation (influenced) of CL-RI
13) Confidence 0.00 Published 2011 Journal J Ovarian Res Section Body Doc Link PMC3024996 Disease Relevance 0 Pain Relevance 0

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