INT11859

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Context Info
Confidence 0.61
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 44
Total Number 44
Disease Relevance 22.62
Pain Relevance 9.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 6
plasma 3
saliva 3
coronary sinus 2
blood 1
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 9 100.00 Very High Very High Very High
antagonist 23 99.88 Very High Very High Very High
Angina 58 99.68 Very High Very High Very High
Pain 26 99.50 Very High Very High Very High
cva 78 99.48 Very High Very High Very High
Serotonin 13 99.48 Very High Very High Very High
Inflammatory mediators 6 99.48 Very High Very High Very High
c fibre 6 99.40 Very High Very High Very High
COX-2 inhibitor 49 99.04 Very High Very High Very High
Migraine 18 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Disease 82 99.84 Very High Very High Very High
Sepsis 54 99.84 Very High Very High Very High
Adhesions 23 99.80 Very High Very High Very High
Cv General 3 Under Development 113 99.68 Very High Very High Very High
Injury 21 99.56 Very High Very High Very High
Pain 24 99.50 Very High Very High Very High
INFLAMMATION 138 99.48 Very High Very High Very High
Thrombosis 34 99.40 Very High Very High Very High
Migraine Without Aura 2 99.28 Very High Very High Very High
Cough 20 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test.
Positive_regulation (elevated) of TxA2 in plasma
1) Confidence 0.61 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.86 Pain Relevance 0.55
These findings indicate that increased TXA2 in circulating plasma is closely correlated with the hypersensitivity of coronary arteries to EM in patients with variant angina, suggesting a possible role of augmented TXA2 production in the enhancement of coronary vascular spasticity.
Positive_regulation (increased) of TXA2 in plasma associated with angina, spasticity and hypersensitivity
2) Confidence 0.59 Published 1987 Journal Jpn. Circ. J. Section Abstract Doc Link 3626009 Disease Relevance 1.07 Pain Relevance 0.45
In relation to the control group we observed a significant decrease in the plasma levels of PGI2 together with a sharp increase in TXA2 in saliva.
Positive_regulation (increase) of TXA2 in saliva
3) Confidence 0.59 Published 1991 Journal Headache Section Abstract Doc Link 2071393 Disease Relevance 0.33 Pain Relevance 0.37
Our results suggest calcium entry into the cytosol as an explanation for the increase in PGE2 and TXA2.
Positive_regulation (increase) of TXA2
4) Confidence 0.58 Published 1989 Journal Headache Section Abstract Doc Link 2793453 Disease Relevance 0.50 Pain Relevance 0.53
Augmentation of TXA2 was also observed in patients with acute myocardial infarction.
Positive_regulation (Augmentation) of TXA2 associated with myocardial infarction
5) Confidence 0.53 Published 1988 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 3137347 Disease Relevance 0.44 Pain Relevance 0.22
These data suggest that: in normal subjects TXA2 and PGI2 increase during exercise, PGI2 increasing more than TXA2, and although coronary disease patients have resting TXA2 and PGI2 levels in the normal range, TXA2 levels increase more than PGI2 levels during exercise.
Positive_regulation (increase) of TXA2 associated with coronary heart disease
6) Confidence 0.49 Published 1983 Journal Am. Heart J. Section Abstract Doc Link 6344604 Disease Relevance 0.42 Pain Relevance 0.12
When the patients were treated with nicardipine, a calcium antagonist, the TXA2 increase in saliva did not occur.
Positive_regulation (increase) of TXA2 in saliva associated with antagonist
7) Confidence 0.45 Published 1991 Journal Headache Section Abstract Doc Link 2071393 Disease Relevance 0.33 Pain Relevance 0.38
Platelet activation, with subsequent formation of thromboxane A2 (TxA2), is thought to play a role in the development of arterial occlusion.
Positive_regulation (formation) of TxA2 in Platelet
8) Confidence 0.45 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.42 Pain Relevance 0.16
Platelet activation, with subsequent formation of thromboxane A2 (TxA2), is thought to play a role in the development of arterial occlusion.
Positive_regulation (formation) of thromboxane A2 in Platelet
9) Confidence 0.45 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.42 Pain Relevance 0.16
In patients with severe atherosclerosis of the lower limbs, characterized by leg ulcers and rest pain, the basal formation of TxA2 and prostacyclin (PGI2) is increased.
Positive_regulation (increased) of TxA2 in leg associated with pain, leg ulcer and increased venous pressure under development
10) Confidence 0.45 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.53 Pain Relevance 0.24
Present results indicate that in platelets from anginal patients phospholipid fatty acid composition is at least in part independent of plasma composition and that in active angina there are modifications leading to increased TxA2 formation and possibly contributing to the occurrence of ischemic attacks.
Positive_regulation (increased) of TxA2 in plasma associated with angina
11) Confidence 0.44 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3024352 Disease Relevance 0.47 Pain Relevance 0.47
Recent developments in measurement techniques and the availability of both selective inhibitors of Tx synthetase and TxA2 receptor antagonists have facilitated the implication of TxA2 as a physiological modulator and as a mediator in thrombotic, vasospastic, and bronchospastic conditions.
Positive_regulation (facilitated) of TxA2 associated with antagonist
12) Confidence 0.43 Published 1987 Journal Fed. Proc. Section Abstract Doc Link 2948837 Disease Relevance 0.34 Pain Relevance 0.13
To clarify the role of thromboxane A2 (TXA2) in evoking coronary spasm, we compared coronary arterial spasticity induced by ergonovine maleate (EM) with coronary sinus thromboxane B2 (TXB2: a stable catabolite of TXA2) in 34 patients with documented variant angina and 11 patients with chest pain syndrome (CPS).
Positive_regulation (role) of thromboxane A2 in coronary sinus associated with complex regional pain syndromes, angina, spasticity and cva
13) Confidence 0.43 Published 1987 Journal Jpn. Circ. J. Section Abstract Doc Link 3626009 Disease Relevance 0.72 Pain Relevance 0.37
To clarify the role of thromboxane A2 (TXA2) in evoking coronary spasm, we compared coronary arterial spasticity induced by ergonovine maleate (EM) with coronary sinus thromboxane B2 (TXB2: a stable catabolite of TXA2) in 34 patients with documented variant angina and 11 patients with chest pain syndrome (CPS).
Positive_regulation (role) of TXA2 in coronary sinus associated with complex regional pain syndromes, angina, spasticity and cva
14) Confidence 0.43 Published 1987 Journal Jpn. Circ. J. Section Abstract Doc Link 3626009 Disease Relevance 0.72 Pain Relevance 0.37
In patients with FA keeping diet No. 10, the platelets were found to be able to generate TxA2 under the influence of ADP, while in those on EPA-rich diet, the latter failed to exhibit this capacity.
Positive_regulation (generate) of TxA2 in platelets associated with angina
15) Confidence 0.40 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2290264 Disease Relevance 0.54 Pain Relevance 0.44
These data suggest that: in normal subjects TXA2 and PGI2 increase during exercise, PGI2 increasing more than TXA2, and although coronary disease patients have resting TXA2 and PGI2 levels in the normal range, TXA2 levels increase more than PGI2 levels during exercise.
Positive_regulation (increase) of TXA2 associated with coronary heart disease
16) Confidence 0.40 Published 1983 Journal Am. Heart J. Section Abstract Doc Link 6344604 Disease Relevance 0.44 Pain Relevance 0.11
Increase in PGE2 and TXA2 in the saliva of common migraine patients.
Positive_regulation (Increase) of TXA2 in saliva associated with migraine and migraine without aura
17) Confidence 0.39 Published 1989 Journal Headache Section Title Doc Link 2793453 Disease Relevance 0.51 Pain Relevance 0.56
Mice with an absent prostaglandin receptor (IPKO) should mimic the clinical effect of taking COX-2 agents, as these drugs would inhibit prostaglandin production without affecting TXA2.
Neg (without) Positive_regulation (affecting) of TXA2
18) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.66 Pain Relevance 0.20
PC3 cells express a large intracellular pool of thromboxane receptor and both the TP?
Positive_regulation (pool) of thromboxane receptor
19) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
Generation of epitope-tagged thromboxane receptor
Positive_regulation (tagged) of thromboxane receptor
20) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0

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