INT118590

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.14
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 1
neurons 1
neural 1
ventral 1
OFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 12 100.00 Very High Very High Very High
midbrain 6 100.00 Very High Very High Very High
Nucleus accumbens 6 99.92 Very High Very High Very High
Anterior cingulate cortex 104 98.70 Very High Very High Very High
Anterior cingulate 30 98.64 Very High Very High Very High
depression 5 95.96 Very High Very High Very High
imagery 5 94.28 High High
amygdala 2 92.60 High High
Hippocampus 19 91.32 High High
Locus ceruleus 22 84.04 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 2 99.84 Very High Very High Very High
Depression 5 95.96 Very High Very High Very High
Injury 2 95.72 Very High Very High Very High
Cognitive Disorder 17 83.68 Quite High
Urological Neuroanatomy 1 75.00 Quite High
Aggression 28 73.08 Quite High
Anxiety Disorder 34 68.48 Quite High
Helminth Infection 10 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 9 5.00 Very Low Very Low Very Low
Sweat Gland Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, human participants in a ‘prisoner's dilemma’ game show activity in all of the familiar reward-related regions when they engage in bouts of cooperative behaviour with their playing partners: OFC; nucleus accumbens; caudate; and ACC (Rilling et al. 2002).
OFC Binding (engage) of in nucleus accumbens associated with nucleus accumbens and anterior cingulate
1) Confidence 0.32 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581784 Disease Relevance 0 Pain Relevance 0.23
It is proposed that both drug-induced and developmental abnormalities in the integrity of OFC neurons may lead to deficits in social behavior or other behavioral pathologies, possibly including depression.
OFC Binding (integrity) of in neurons associated with depression and congenital anomalies
2) Confidence 0.32 Published 2004 Journal Brain Cogn Section Abstract Doc Link 15134846 Disease Relevance 0.68 Pain Relevance 0.11
The total cholesterol increase associated with OFC was more pronounced than with olanzapine alone.


OFC Binding (associated) of
3) Confidence 0.24 Published 2009 Journal J Clin Psychiatry Section Body Doc Link 19284928 Disease Relevance 0 Pain Relevance 0
Such direct and immediate reinforcers are typically referred to as primary rewards, and, as reviewed above, are associated with the activation of midbrain dopamine neurons, as well as neurons in the ventral striatum and OFC, among other areas.
OFC Binding (associated) of in ventral associated with dopamine and midbrain
4) Confidence 0.24 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581784 Disease Relevance 0.11 Pain Relevance 0.21
Random cholesterol mean change (mg/dL) was +12.4 for OFC, +2.3 for fluoxetine (p < .001), and +3.1 for olanzapine (p < .001); incidence of treatment-emergent increase from normal to high cholesterol (baseline < 200 mg/dL and >or= 240 subsequently) was significantly higher for the OFC group (10.2%) than for the fluoxetine group (3.1%, p = .017) but not the olanzapine group (8.0%, p = .569).
OFC Binding (+12.4) of
5) Confidence 0.19 Published 2009 Journal J Clin Psychiatry Section Body Doc Link 19284928 Disease Relevance 0 Pain Relevance 0
Further post hoc Bonferroni tests revealed that ACC lesion animals spent significantly less time engaging in social interaction than both OFC and sham lesion animals (P < 0.001).
OFC Binding (interaction) of associated with anterior cingulate cortex
6) Confidence 0.10 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.21 Pain Relevance 0.18
Collectively, these results suggest that the OFC and HPC contribute to an extended neural circuitry underlying intertemporal choice, cost-benefit decision making, which presumably also includes brain areas such as the nucleus accumbens and basolateral amygdala (Cardinal, Pennicott, Sugathapala, Robbins, & Everitt, 2001; Pothuizen, Jongen-Relo, Feldon, & Yee, 2005; Winstanley, Theobald, Cardinal, & Robbins, 2004).
OFC Binding (contribute) of in neural associated with nucleus accumbens and amygdala
7) Confidence 0.02 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.14 Pain Relevance 0.18

General Comments

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