INT118606

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Context Info
Confidence 0.86
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.98
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
lymphocytes 1
natural killer cells 1
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Restless leg syndrome 1 94.72 High High
Inflammation 28 94.36 High High
chemokine 58 85.68 High High
cytokine 53 83.68 Quite High
Arthritis 88 71.68 Quite High
antagonist 4 68.16 Quite High
Inflammatory mediators 4 59.76 Quite High
spinal inflammation 38 49.52 Quite Low
rheumatoid arthritis 44 48.48 Quite Low
psoriasis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 94.72 High High
INFLAMMATION 30 94.36 High High
Chronic Hepatitis 1 92.84 High High
Arthritis 54 71.68 Quite High
Low Back Pain 38 49.52 Quite Low
Rheumatoid Arthritis 44 48.48 Quite Low
Disease 2 39.60 Quite Low
Arthropathy 6 34.96 Quite Low
Seronegative Spondarthritis 34 29.60 Quite Low
Autoimmune Disease 2 9.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro.
Protein_catabolism (degradation) of interferon-gamma-induced
1) Confidence 0.86 Published 2004 Journal Int. Immunopharmacol. Section Title Doc Link 15135323 Disease Relevance 0.28 Pain Relevance 0.12
These CXCR3-expressing cells themselves therefore also contribute to CXCL10 degradation, providing a negative feedback loop that prevents further infiltration of activated Th1 lymphocytes and natural killer cells to the site of inflammation.
Protein_catabolism (degradation) of CXCL10 in natural killer cells associated with inflammation
2) Confidence 0.58 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.35 Pain Relevance 0.55
These CXCR3-expressing cells themselves therefore also contribute to CXCL10 degradation, providing a negative feedback loop that prevents further infiltration of activated Th1 lymphocytes and natural killer cells to the site of inflammation.
Protein_catabolism (degradation) of CXCL10 in lymphocytes associated with inflammation
3) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.35 Pain Relevance 0.55

General Comments

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