INT118615

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 13.79
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
blood 2
monocyte 1
nasal 1
immune system 1
eosinophil 1
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 891 100.00 Very High Very High Very High
Inflammation 981 99.76 Very High Very High Very High
antagonist 283 96.88 Very High Very High Very High
agonist 174 94.00 High High
rheumatoid arthritis 81 93.36 High High
tolerance 10 88.72 High High
chemokine 203 88.12 High High
aspirin 56 70.08 Quite High
cINOD 24 66.16 Quite High
Kinase C 1 63.20 Quite High
Disease Link Frequency Relevance Heat
Disease 255 99.90 Very High Very High Very High
Asthma 2655 99.88 Very High Very High Very High
Pneumonia 61 99.88 Very High Very High Very High
INFLAMMATION 1073 99.76 Very High Very High Very High
Eosinophilia 193 99.46 Very High Very High Very High
Hypersensitivity 140 99.36 Very High Very High Very High
Granuloma 1 99.34 Very High Very High Very High
Apoptosis 86 99.32 Very High Very High Very High
Rhinitis 146 99.20 Very High Very High Very High
Autoimmune Disease 36 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 14 kD IL-4 mutein that blocks IL-4R?
Negative_regulation (blocks) of IL-4
1) Confidence 0.41 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.44 Pain Relevance 0.03
With respect to the increase of IL-4, the combination was significantly additive to the effect of either IL-7 or IL-4 alone.


Negative_regulation (effect) of IL-4
2) Confidence 0.34 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.38 Pain Relevance 0.19
These findings correlated with decreased levels of IL-4 and IL-5 in the airways in NES-treated animals [316].
Negative_regulation (decreased) of IL-4
3) Confidence 0.25 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.10 Pain Relevance 0
They also showed a decrease in serum levels of sIL-2R, IL-4, IL-5, IgE and eosinophil count.
Negative_regulation (decrease) of IL-4 in eosinophil
4) Confidence 0.22 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.48 Pain Relevance 0.10
It is unclear if there is a problem with the specific monoclonal antibodies that have been developed or if there is too much redundancy in the immune system such that inhibiting either IL-4 or IL-13 is insufficient.
Negative_regulation (inhibiting) of IL-4 in immune system
5) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.50 Pain Relevance 0.03
These data support the potential utility of a dual IL-4 and IL-13 oligonucleotide inhibitor in asthma, and suggest that local inhibition of IL-4R?
Negative_regulation (inhibitor) of IL-4 associated with asthma
6) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.01 Pain Relevance 0.22
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Negative_regulation (decrease) of IL-4 in nasal associated with rhinitis
7) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.86 Pain Relevance 0.41
Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and CCL11 production [150,151].
Negative_regulation (inhibition) of IL-4
8) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.27 Pain Relevance 0.16
IL-4 blockers and asthma
Negative_regulation (blockers) of IL-4 associated with asthma
9) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.21 Pain Relevance 0.53
, and to suppress Th2 cytokine genes such as IL-4 and IL-5 in Th2 cells [148,149].
Negative_regulation (suppress) of IL-4 in Th2 cells associated with cytokine
10) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.18 Pain Relevance 0.17
Interestingly, expression of GATA-3, CCR3, -4, -8, and ST2L, and the generation of blood eosinophilia, is intact in mice doubly deficient in both IL-4 and IL-13 [304].
Negative_regulation (deficient) of IL-4 in blood associated with eosinophilia
11) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.22 Pain Relevance 0.11
A novel approach is represented by an IL-4 peptide-based vaccine for blocking IL-4 on a persistent basis.
Negative_regulation (blocking) of IL-4
12) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.10 Pain Relevance 0.19
Robust IL-9 expression was detected in IL-4+TGF-?
Negative_regulation (detected) of IL-4
13) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.09
This effect is due to loss of a receptor for IL-4 during monocyte differentiation [53].
Negative_regulation (loss) of IL-4 in monocyte
14) Confidence 0.12 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.09 Pain Relevance 0.19
Senel et al [14] reported a combination of cyclosporine, azathioprine and prednisolone to be successful in treatment of KD and decreasing serum levels of soluble IL-2 receptor (sIL-2R), IL-4 and IL-5 consequently.
Negative_regulation (decreasing) of IL-4 associated with disease
15) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.48 Pain Relevance 0.09
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decreased) of IL-4 in blood
16) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.79 Pain Relevance 0.15
MPC apoptosis was induced by the addition of a combination of 30 ng/ml IL-4 and 30,000 U/ml IFN?
Negative_regulation (combination) of IL-4 associated with apoptosis
17) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.19 Pain Relevance 0
in granulomas and areas with pneumonitis with reductions in IL-10 and IL-4 compared to controls [22].
Negative_regulation (reductions) of IL-4 associated with pneumonia and granuloma
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.86 Pain Relevance 0.12
In humans, before treatment with androgens, patients who have Klinefelter's syndrome but not RAD have very diminished levels of testosterone associated with high levels of IgG, IgA, IgM, IL-2, and IL-4 and with an absolute increase of CD3+, CD4+, and the CD4+/CD8+ ratio [30].
Negative_regulation (levels) of IL-4 associated with autoimmune disease and syndrome
19) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64847 Disease Relevance 0.86 Pain Relevance 0.06
It has been shown in an allergic airway inflammation model that suppress both IL-4 and IL-13 may be necessary to reduce mucus production and allergic inflammation (74).
Negative_regulation (suppress) of IL-4 associated with inflammation and hypersensitivity
20) Confidence 0.02 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 2.31 Pain Relevance 0.33

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