INT118644

Context Info Confidence 0.45 First Reported 2004 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.43 Pain Relevance 3.60

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)

Anatomy Link Frequency spinal 1 spinal cord 1 Slc12a2 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 17 98.92 qutenza 40 97.46 Pain 29 97.00 Thermal hyperalgesia 1 96.64 Spinal cord 7 95.68 Dorsal horn 7 94.80 dorsal root ganglion 7 92.44 allodynia 80 90.36 Inflammation 13 89.96 GABAergic 19 88.64

Disease Link Frequency Relevance Heat Pain 16 97.00 Hyperalgesia 26 96.64 Ganglion Cysts 7 92.44 Targeted Disruption 4 91.36 Neuropathic Pain 81 90.36 INFLAMMATION 15 89.96 Fungal Infection 12 87.00 Infection 28 85.88 Disease 9 82.76 Low Back Pain 1 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have examined the role of the NKCC1 sodium-potassium-chloride-cotransporter in the generation of touch-evoked pain.

Spec (examined) Regulation (role) of NKCC1 associated with pain

1) Confidence 0.45 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135928 Disease Relevance 0.62 Pain Relevance 0.70

The majority of these neurons also express NKCC1 [29], hence, we reasoned that spinal TRPV1 receptors might be involved in regulating NKCC1 activity.

Regulation (regulating) of NKCC1 in spinal

2) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.08 Pain Relevance 1.39

Intracolonic capsaicin also evoked a rapid (10 min) and transient phosphorylation of NKCC1, however, intracolonic saline did not produce significant changes in either NKCC1 trafficking or phosphorylation and none of the treatments induced any alterations of NKCC1 in the thoracic spinal cord.

Regulation (changes) of NKCC1 in spinal cord associated with qutenza and spinal cord

3) Confidence 0.39 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.35 Pain Relevance 1.10

The ontogenetic shift to hyperpolarizing GABA action is caused by a concomitant developmental down-regulation of NKCC1 and an up-regulation of a K+–Cl?

Regulation (regulation) of NKCC1 associated with gaba

4) Confidence 0.13 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.42

Regulation of ABC transporters is therefore of pivotal importance to understanding azole resistance.

Regulation (Regulation) of transporters

5) Confidence 0.00 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2607542 Disease Relevance 0.33 Pain Relevance 0

Irrespective of the precise molecular mechanism involved, our results strongly suggest that CgPDR1 GOF mutations have differentiated effects on target genes including the major ABC-transporters involved in azole resistance.

Regulation (effects) of transporters

6) Confidence 0.00 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.06 Pain Relevance 0

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