INT118644

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.43
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Anatomy Link Frequency
spinal 1
spinal cord 1
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 17 98.92 Very High Very High Very High
qutenza 40 97.46 Very High Very High Very High
Pain 29 97.00 Very High Very High Very High
Thermal hyperalgesia 1 96.64 Very High Very High Very High
Spinal cord 7 95.68 Very High Very High Very High
Dorsal horn 7 94.80 High High
dorsal root ganglion 7 92.44 High High
allodynia 80 90.36 High High
Inflammation 13 89.96 High High
GABAergic 19 88.64 High High
Disease Link Frequency Relevance Heat
Pain 16 97.00 Very High Very High Very High
Hyperalgesia 26 96.64 Very High Very High Very High
Ganglion Cysts 7 92.44 High High
Targeted Disruption 4 91.36 High High
Neuropathic Pain 81 90.36 High High
INFLAMMATION 15 89.96 High High
Fungal Infection 12 87.00 High High
Infection 28 85.88 High High
Disease 9 82.76 Quite High
Low Back Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined the role of the NKCC1 sodium-potassium-chloride-cotransporter in the generation of touch-evoked pain.
Spec (examined) Regulation (role) of NKCC1 associated with pain
1) Confidence 0.45 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135928 Disease Relevance 0.62 Pain Relevance 0.70
The majority of these neurons also express NKCC1 [29], hence, we reasoned that spinal TRPV1 receptors might be involved in regulating NKCC1 activity.
Regulation (regulating) of NKCC1 in spinal
2) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.08 Pain Relevance 1.39
Intracolonic capsaicin also evoked a rapid (10 min) and transient phosphorylation of NKCC1, however, intracolonic saline did not produce significant changes in either NKCC1 trafficking or phosphorylation and none of the treatments induced any alterations of NKCC1 in the thoracic spinal cord.
Regulation (changes) of NKCC1 in spinal cord associated with qutenza and spinal cord
3) Confidence 0.39 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.35 Pain Relevance 1.10
The ontogenetic shift to hyperpolarizing GABA action is caused by a concomitant developmental down-regulation of NKCC1 and an up-regulation of a K+–Cl?
Regulation (regulation) of NKCC1 associated with gaba
4) Confidence 0.13 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.42
Regulation of ABC transporters is therefore of pivotal importance to understanding azole resistance.
Regulation (Regulation) of transporters
5) Confidence 0.00 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2607542 Disease Relevance 0.33 Pain Relevance 0
Irrespective of the precise molecular mechanism involved, our results strongly suggest that CgPDR1 GOF mutations have differentiated effects on target genes including the major ABC-transporters involved in azole resistance.
Regulation (effects) of transporters
6) Confidence 0.00 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.06 Pain Relevance 0

General Comments

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