INT118675

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.58
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
hippocampus 6
neuronal 2
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 34 100.00 Very High Very High Very High
Opioid 9 99.84 Very High Very High Very High
psychological dependence 3 99.52 Very High Very High Very High
Morphine 15 99.48 Very High Very High Very High
fluoxetine 7 98.64 Very High Very High Very High
Anterior cingulate cortex 84 91.72 High High
addiction 6 69.48 Quite High
Glutamate 6 65.76 Quite High
Desipramine 1 65.60 Quite High
bDMF 3 56.60 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 3 99.52 Very High Very High Very High
Urological Neuroanatomy 14 99.12 Very High Very High Very High
Anxiety Disorder 249 93.28 High High
Pain 12 52.32 Quite High
Targeted Disruption 24 50.48 Quite High
Shock 69 48.04 Quite Low
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is the first evidence to suggest that the increased CREB phosphorylation via CaMKIV signal pathway in hippocampus is relevant to opioids psychological dependence.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CaMKIV in hippocampus associated with psychological dependence, hippocampus and opioid
1) Confidence 0.66 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0.10 Pain Relevance 0.55
Thus CaMKIV mediated phosphorylation of CREB may be a major mediator of this consolidation, in part through enhancement of local slow delta oscillations during NREM sleep.
Positive_regulation (mediator) of Phosphorylation (phosphorylation) of CaMKIV
2) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.49 Pain Relevance 0.25
Thus CaMKIV mediated phosphorylation of CREB may be a major mediator of this consolidation, in part through enhancement of local slow delta oscillations during NREM sleep.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of CaMKIV
3) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.43 Pain Relevance 0.19
CaMKIV is a serine-threonine kinase and is activated by a combination of elevated intracellular Ca2+ and CaMK kinase during neuronal activity [for review, see [25] and phosphorylates CREB [26,27]].
Positive_regulation (activated) of Phosphorylation (phosphorylates) of CaMKIV in neuronal
4) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.05 Pain Relevance 0.03
This is the first evidence to suggest that the increased CREB phosphorylation via CaMKIV signal pathway in hippocampus is relevant to opioids psychological dependence.
Positive_regulation (relevant) of Phosphorylation (phosphorylation) of CaMKIV in hippocampus associated with psychological dependence, hippocampus and opioid
5) Confidence 0.47 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0.10 Pain Relevance 0.55
The results showed that F9202, F9204 or morphine, which could induce CPP, enhanced CREB phosphorylation and the expression of CaMKIV in hippocampus from CPP mice without affecting total CREB protein level.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of CaMKIV in hippocampus associated with hippocampus and morphine
6) Confidence 0.38 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.71
Activation of this kinase was due to increased phosphorylation of the activatory residue Thr196, with no major changes in the expression levels of alpha- and beta-CaM kinase kinase, enzymes that phosphorylate CaMKIV.
Positive_regulation (phosphorylate) of Phosphorylation (phosphorylate) of CaMKIV
7) Confidence 0.19 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.41 Pain Relevance 0.64

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