INT118676

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 34
Total Number 42
Disease Relevance 16.67
Pain Relevance 10.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
ACC neurons 2
PFCX 2
neuronal 1
brain 1
nucleus 1
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 29 100.00 Very High Very High Very High
long-term potentiation 959 99.98 Very High Very High Very High
Inflammation 29 99.84 Very High Very High Very High
fluoxetine 25 99.72 Very High Very High Very High
Anterior cingulate cortex 1186 99.52 Very High Very High Very High
antidepressant 7 99.42 Very High Very High Very High
Hippocampus 137 99.04 Very High Very High Very High
withdrawal 4 98.34 Very High Very High Very High
Glutamate receptor 17 97.96 Very High Very High Very High
qutenza 74 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 687 100.00 Very High Very High Very High
Repression 469 99.98 Very High Very High Very High
Sleep Disorders 11 99.96 Very High Very High Very High
INFLAMMATION 34 99.84 Very High Very High Very High
Anxiety Disorder 1224 99.64 Very High Very High Very High
Shock 298 99.16 Very High Very High Very High
Urological Neuroanatomy 51 98.56 Very High Very High Very High
Syndrome 2 96.56 Very High Very High Very High
Schizophrenia 9 95.88 Very High Very High Very High
Intellectual Impairment 1 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKIV is a serine-threonine kinase and is activated by a combination of elevated intracellular Ca2+ and CaMK kinase during neuronal activity [for review, see [25] and phosphorylates CREB [26,27]].
Positive_regulation (activated) of CaMKIV in neuronal
1) Confidence 0.70 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0 Pain Relevance 0.03
During synaptic potentiation within the ACC, we have reported that activation of AC1 and CaMKIV is important among the CaM target proteins mentioned above [19,25].
Positive_regulation (activation) of CaMKIV associated with anterior cingulate cortex
2) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.05 Pain Relevance 0.63
When the tone was played on the testing day, post-hoc analysis revealed that 4-7.5 Hz power was increased for CaMKIV mice (t = 6.73; p < 0.001) but not WT mice (t = 0.331; p = 1.0) compared to their respective baseline.
Positive_regulation (increased) of CaMKIV
3) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.24 Pain Relevance 0
Post-hoc analysis revealed that 2-4 Hz power was increased in CaMKIV over-expressed mice (t = 3.12; p < 0.010) during the expected shock test condition, compared to baseline (Figure 4B).
Positive_regulation (increased) of CaMKIV associated with shock
4) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.83 Pain Relevance 0.08
However we did not observe any increase in CaMKIV mice above that of WT mice in the high frequency EEG range during the training trials (for frequencies greater than 13 Hz).
Positive_regulation (increase) of CaMKIV
5) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.50 Pain Relevance 0.31
CaMKIV is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium (Ca2+).
Positive_regulation (activated) of CaMKIV
6) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.35 Pain Relevance 0.14
Among them, we found that activation of AC1 and CaMKIV is essential for the induction of LTP in the ACC [11,15].
Positive_regulation (activation) of CaMKIV associated with long-term potentiation and anterior cingulate cortex
7) Confidence 0.54 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.66
Among them, activation of AC1 and CaMKIV have been reported to be essential for the induction of LTP in the ACC [4,9].
Positive_regulation (activation) of CaMKIV associated with long-term potentiation and anterior cingulate cortex
8) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.58
Activity-dependent activation of CaMKIV is critical for LTP induction in the ACC and is also critical for ACC-related brain functions such as trace fear memory [20].
Positive_regulation (activation) of CaMKIV in brain associated with anxiety disorder, long-term potentiation and anterior cingulate cortex
9) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.49 Pain Relevance 0.38
Considering that the CaMKIV-CREB pathway plays a central role in the protein synthesis-dependent LTP, it is possible that upregulation of CaMKIV contributes to enhancement of LTP by promoting protein synthesis.
Spec (possible) Positive_regulation (upregulation) of CaMKIV associated with long-term potentiation
10) Confidence 0.46 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2949850 Disease Relevance 0.28 Pain Relevance 0.40
While these molecules are critical for synaptic scaling during activity blockade, additional cell autonomous mechanisms are also necessary, such as reduced CaMKIV activation and transcriptional changes (Ibata et al. 2008).
Positive_regulation (activation) of CaMKIV
11) Confidence 0.44 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.63 Pain Relevance 0.06
The foot shock given during fear conditioning caused an increase in 30 kHz USVs in both wild-type and CaMKIV-/- mice.
Positive_regulation (increase) of CaMKIV in foot associated with anxiety disorder and shock
12) Confidence 0.44 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1079936 Disease Relevance 0.75 Pain Relevance 0.27
Indeed, our preliminary studies (unpublished) suggest that there is no obvious difference in slow wave sleep recovery as a consequence of 4 hours of sleep deprivation, induced with novel objects and gentle handling in CaMKIV mice.


Neg (no) Positive_regulation (induced) of CaMKIV associated with sleep disorders
13) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.63 Pain Relevance 0
Four-7.5 Hz power was also significantly elevated in CaMKIV over-expressed mice above baseline during the testing phase (~24 hours later) (p < 0.05, as in Figure 5A).
Positive_regulation (elevated) of CaMKIV
14) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.28 Pain Relevance 0
This result demonstrates that genetic enhancement of learning and memory (Figure 3A) also potentiates EEG activity during subsequent sleep in CaMKIV over-expressed mice, linking genetics, sleep and memory through the CaMKIV protein.
Positive_regulation (potentiates) of CaMKIV
15) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.29 Pain Relevance 0
Since 4-7.5 Hz oscillations are enhanced in CaMKIV mice during learning and memory, above that of baseline and WT mice (Figure 4), we expected that these oscillations might represent neural correlates of attention or memory of the expected shock during the trace interval.
Positive_regulation (enhanced) of CaMKIV in neural associated with shock
16) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.60 Pain Relevance 0.09
Wu et al analyzed only fear memory and did not assess anxiety-like behaviors, thus it is possible that anxiety-like behavior is enhanced in CaMKIV TG mice[37].
Positive_regulation (enhanced) of CaMKIV associated with anxiety disorder
17) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.61 Pain Relevance 0
In the present study, we found that transcription- and translation-dependent synaptic potentiation was markedly enhanced in CaMKIV transgenic mice at 0-5, 15-20 and 25-30 min after induction of LTP.
Positive_regulation (enhanced) of CaMKIV transgenic associated with targeted disruption and long-term potentiation
18) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.25 Pain Relevance 0.64
In our behavioral study, trace fear memory was significantly enhanced in CaMKIV transgenic mice, suggesting that CaMKIV affects the ability to sustain attention in a manner needed for retaining of the memory [20], although its mechanism remains unknown.
Positive_regulation (enhanced) of CaMKIV transgenic associated with targeted disruption and anxiety disorder
19) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.45 Pain Relevance 0.66
Behavioral withdrawal responses to acute thermal or mechanical noxious responses or inflammation do not require the activity of CaMKIV [10], but emotional responses (i.e., USVs) may require the involvement of CaMKIV.


Neg (not) Positive_regulation (require) of CaMKIV associated with inflammation and withdrawal
20) Confidence 0.41 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.93 Pain Relevance 0.77

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