INT118677

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 10 99.92 Very High Very High Very High
long-term potentiation 116 99.12 Very High Very High Very High
Hippocampus 11 99.04 Very High Very High Very High
Anterior cingulate cortex 34 98.68 Very High Very High Very High
antidepressant 2 95.32 Very High Very High Very High
nMDA receptor 18 81.00 Quite High
Calcium channel 1 76.40 Quite High
depression 6 75.72 Quite High
Desipramine 1 75.48 Quite High
Glutamate 4 71.00 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 15 82.64 Quite High
Non-genital Cutaneous Warts 3 78.52 Quite High
Depression 6 75.72 Quite High
Urological Neuroanatomy 5 70.44 Quite High
Necrosis 1 54.96 Quite High
Cancer 1 54.60 Quite High
Injury 1 45.40 Quite Low
Pain 5 44.88 Quite Low
Anxiety Disorder 6 10.36 Low Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among them, activation of AC1 and CaMKIV have been reported to be essential for the induction of LTP in the ACC [4,9].
Positive_regulation (essential) of Positive_regulation (activation) of CaMKIV associated with long-term potentiation and anterior cingulate cortex
1) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.61
While these molecules are critical for synaptic scaling during activity blockade, additional cell autonomous mechanisms are also necessary, such as reduced CaMKIV activation and transcriptional changes (Ibata et al. 2008).
Positive_regulation (necessary) of Positive_regulation (activation) of CaMKIV
2) Confidence 0.32 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.63 Pain Relevance 0.09
Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades.
Positive_regulation (linked) of Positive_regulation (activation) of kinase IV associated with fluoxetine
3) Confidence 0.20 Published 2004 Journal Neuropsychopharmacology Section Title Doc Link 15138445 Disease Relevance 0.20 Pain Relevance 0.54

General Comments

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