INT118683

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.92
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
colon 2
PFCX 2
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 64 99.64 Very High Very High Very High
fluoxetine 7 98.82 Very High Very High Very High
agonist 8 98.80 Very High Very High Very High
antagonist 18 97.12 Very High Very High Very High
Osteoarthritis 178 94.20 High High
rheumatoid arthritis 198 93.92 High High
cINOD 10 70.64 Quite High
Endocannabinoid 86 69.00 Quite High
Hippocampus 1 65.60 Quite High
Desipramine 1 61.64 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 6 99.70 Very High Very High Very High
Apoptosis 5 99.38 Very High Very High Very High
Urological Neuroanatomy 5 98.72 Very High Very High Very High
Frailty 180 94.20 High High
Rheumatoid Arthritis 198 93.92 High High
Cancer 9 71.60 Quite High
INFLAMMATION 64 70.44 Quite High
Disease 26 5.00 Very Low Very Low Very Low
Arthritis 18 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Again in PFCX, FLX selectively increased the expression level of MAP kinases Erk1/2, without affecting their phosphorylation.
Neg (without) Regulation (affecting) of Phosphorylation (phosphorylation) of Erk1 in PFCX associated with urological neuroanatomy and fluoxetine
1) Confidence 0.44 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.40 Pain Relevance 0.61
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Neg (without) Regulation (modulating) of Phosphorylation (phosphorylation) of ERK1 in colon associated with colon cancer and apoptosis
2) Confidence 0.44 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.13 Pain Relevance 0.14
M) produced a time-dependent phosphorylation of ERK1, ERK2, and p38 MAPK, indicating an increase in ERK and p38 activity which peaked at 10 minutes after stimulation (Figure 6).
Regulation (dependent) of Phosphorylation (phosphorylation) of ERK1
3) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.04 Pain Relevance 0.65
To further investigate the role of the cannabinoid receptors in mediating the effects of HU210 on phosphorylation of ERK1, ERK2, and p38 MAPK, the potential ability of the CB1 and CB2 receptor antagonists SR141716A and SR144528 to block the effects of HU210 (0.1 ?
Regulation (effects) of Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid receptor and antagonist
4) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.35 Pain Relevance 0.42

General Comments

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