INT118699

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.15
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
A549 1
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 99.28 Very High Very High Very High
licofelone 16 98.80 Very High Very High Very High
Pain 2 79.12 Quite High
Stimulus evoked pain 2 75.00 Quite High
Osteoarthritis 2 64.48 Quite High
Arthritis 1 35.04 Quite Low
rheumatoid arthritis 1 32.72 Quite Low
nociceptor 1 25.00 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.28 Very High Very High Very High
Targeted Disruption 8 99.20 Very High Very High Very High
Pain 3 79.12 Quite High
Nociception 1 78.72 Quite High
Hypersensitivity 2 75.00 Quite High
Osteoarthritis 2 64.48 Quite High
Arthritis 1 35.04 Quite Low
Rheumatoid Arthritis 1 32.72 Quite Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparison of PGES activity in the membrane fraction of tissues from mPGES-1 KO and wild-type (WT) mice indicated that mPGES-1 accounted for the majority of lipopolysaccharide (LPS)-inducible PGES in WT mice.
mPGES-1 Binding (accounted) of associated with targeted disruption
1) Confidence 0.33 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15140897 Disease Relevance 0.85 Pain Relevance 0.22
with high affinity have been designated FP receptors; whereas, the receptors that bind PGEs with high affinity are designated as EP1, EP2, EP3, and EP4.
PGEs Binding (bind) of
2) Confidence 0.02 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
We conclude that licofelone suppresses inflammatory PGE(2) formation preferentially by inhibiting mPGES-1 at concentrations that do not affect COX-2, implying an attractive and thus far unique molecular pharmacological dynamics as inhibitor of COX-1, the 5-lipoxygenase pathway, and of mPGES-1.
mPGES-1 Binding (inhibiting) of associated with inflammation and licofelone
3) Confidence 0.02 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550688 Disease Relevance 0.10 Pain Relevance 0.56
However, licofelone efficiently blocked the conversion of PGH(2) to PGE(2) mediated by mPGES-1 (IC(50) = 6 microM) derived from microsomes of interleukin-1beta-treated A549 cells, being about equipotent to 3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid (MK-886), a well recognized mPGES-1 inhibitor.
mPGES-1 Binding (recognized) of in A549 associated with licofelone
4) Confidence 0.01 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550688 Disease Relevance 0.19 Pain Relevance 0.72

General Comments

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