INT118700

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.04
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
macrophage 1
lungs 1
microglia 1
peritoneal macrophages 1
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 100.00 Very High Very High Very High
cytokine 26 99.84 Very High Very High Very High
Pain 11 98.44 Very High Very High Very High
Inflammatory response 7 97.92 Very High Very High Very High
Paracetamol 1 93.92 High High
COX-2 inhibitor 7 84.68 Quite High
Stimulus evoked pain 2 75.00 Quite High
fibrosis 35 73.64 Quite High
rheumatoid arthritis 2 54.24 Quite High
endometriosis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 70 100.00 Very High Very High Very High
Pain 12 98.44 Very High Very High Very High
Injury 6 98.04 Very High Very High Very High
Targeted Disruption 39 97.94 Very High Very High Very High
Hepatotoxicity 1 94.84 High High
Ocular & Orbital Inflammation 1 91.92 High High
Fever 3 91.52 High High
Asthma 8 89.40 High High
Convulsion 1 87.24 High High
Disease 12 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also likely that the activity of PGE synthase (PGES), which produces PGE2 from PGH2, may increase in lungs of CFTR -/- mice.
Spec (may) Positive_regulation (increase) of PGES in lungs
1) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.44 Pain Relevance 0.19
Among them, mPGES-1 is highly inducible by cytokine and is critically involved in pain and inflammatory responses.
Positive_regulation (inducible) of mPGES-1 associated with pain, inflammatory response and cytokine
2) Confidence 0.45 Published 2007 Journal Kidney Int. Section Abstract Doc Link 17495855 Disease Relevance 0.47 Pain Relevance 0.24
Comparison of PGES activity in the membrane fraction of tissues from mPGES-1 KO and wild-type (WT) mice indicated that mPGES-1 accounted for the majority of lipopolysaccharide (LPS)-inducible PGES in WT mice.
Positive_regulation (inducible) of PGES associated with targeted disruption
3) Confidence 0.36 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15140897 Disease Relevance 0.87 Pain Relevance 0.23
Angiotensin II infusion upregulated aortic expression of cyclooxygenase-2 and mPGES-1, increased aortic macrophage recruitment and vascular nitrotyrosine staining (which reflects local oxidative stress), and augmented urinary excretion of the isoprostane 8,12-iso-iPF(2alpha)-VI (which reflects lipid peroxidation in vivo) and the major metabolite of PGE(2) (PGE-M).
Positive_regulation (increased) of mPGES-1 in macrophage
4) Confidence 0.16 Published 2008 Journal Circulation Section Body Doc Link 18285567 Disease Relevance 0.30 Pain Relevance 0
Functional coupling of the inducible enzymes COX-2 and mPGES-1 has been proposed for increased production of PGE(2) in different cell types.
Positive_regulation (inducible) of mPGES-1
5) Confidence 0.06 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.45 Pain Relevance 0.18
Furthermore, LPS induced the expression of Egr-1 that cooperated with NF-kappaB in the up-regulation of COX-2 and mPGES-1.
Positive_regulation (up-regulation) of mPGES-1
6) Confidence 0.06 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.18 Pain Relevance 0.12
Another study reported, in support of our observations, that selective pharmacological inhibition of COX-2 with NS-398 increases the transcription of inflammatory genes (mPGES-1, TLR2, CD14, MCP-1) in vascular associated brain cells and parenchymal microglia after systemic injection of LPS [14].
Positive_regulation (increases) of mPGES-1 in microglia associated with inflammation
7) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.90 Pain Relevance 0.36
The membrane-associated PGES-1 (mPGES-1) is inducible and functionally linked to COX-2, while mPGES-2 is constitutive and coupled to both COX isoforms [11].
Positive_regulation (inducible) of PGES-1
8) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.49 Pain Relevance 0.15
The membrane-associated PGES-1 (mPGES-1) is inducible and functionally linked to COX-2, while mPGES-2 is constitutive and coupled to both COX isoforms [11].
Positive_regulation (inducible) of mPGES
9) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.49 Pain Relevance 0.15
mPGES-1 is a source of inducible PGE2 synthetic activity [47].
Positive_regulation (inducible) of mPGES
10) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.37 Pain Relevance 0.06
Of these isomerases, cPGES and mPGES-2 are constitutive enzymes, whereas mPGES-1 is mainly an induced isomerase. cPGES uses PGH(2) produced by COX-1 whereas mPGES-1 uses COX-2-derived endoperoxide. mPGES-2 can use both sources of PGH(2). mPGES-1 is a member of the membrane associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily.
Positive_regulation (induced) of mPGES-1
11) Confidence 0.03 Published 2007 Journal Pharmacol. Rev. Section Abstract Doc Link 17878511 Disease Relevance 0 Pain Relevance 0
RESULTS: sPLA(2)-IIA, COX-2 and mPGES-1 mRNA was significantly increased in peritoneal macrophages of endometriosis patients compared with controls (P = 0.006, P = 0.016 and P = 0.025, respectively).
Positive_regulation (increased) of mPGES-1 mRNA in peritoneal macrophages
12) Confidence 0.00 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20023295 Disease Relevance 0.08 Pain Relevance 0

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