INT11871

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Context Info
Confidence 0.23
First Reported 1992
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 25
Disease Relevance 1.88
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rnpep) extracellular space (Rnpep) aging (Rnpep)
extracellular region (Rnpep) Golgi apparatus (Rnpep) plasma membrane (Rnpep)
Anatomy Link Frequency
testis 1
Caco-2 1
Rnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 29 99.80 Very High Very High Very High
Inflammation 105 96.80 Very High Very High Very High
Glutamate 63 80.32 Quite High
addiction 21 79.92 Quite High
Neuropeptide 63 72.44 Quite High
tolerance 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 63 97.76 Very High Very High Very High
INFLAMMATION 105 96.80 Very High Very High Very High
Cancer 42 95.04 Very High Very High Very High
Diabetes Mellitus 21 94.04 High High
Aids-related Complex 21 51.76 Quite High
Nocardia Infection 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we determined the activities of four aminopeptidases such as aminopeptidase B (APB), M (APM), N (APN) and dipeptidylpeptidase IV (DPP IV) in Caco-2 cells and compared with those in the rat intestinal mucosae.
Spec (determined) Gene_expression (activities) of aminopeptidase B in Caco-2
1) Confidence 0.23 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.07
Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines.
Gene_expression (Synthesis) of aminopeptidase B associated with enkephalin
2) Confidence 0.13 Published 1992 Journal Arch. Pharm. (Weinheim) Section Title Doc Link 1605710 Disease Relevance 0 Pain Relevance 0.16
The inhibitory effects of compounds 14, 15, 19, and 22, and the related ketomethylene dipeptides (S)Ala psi(COCH2)(R,S)Phe (3), (S)Phe psi(COCH2)(R,S)X [X = Ala (4), Orn (5)] and (S)Trp psi(COCH2)(R,S)Y [Y = Orn (6), Lys (7), Arg (8)] on aminopeptidase B (AP-B), and enkephalin-degrading enzymes [aminopeptidase N (APN) and neutral endopeptidase (NEP)] were compared with that of the model compound 1.
Gene_expression (effects) of AP-B associated with enkephalin
3) Confidence 0.13 Published 1992 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 1605710 Disease Relevance 0 Pain Relevance 0.17
The inhibitory effects of compounds 14, 15, 19, and 22, and the related ketomethylene dipeptides (S)Ala psi(COCH2)(R,S)Phe (3), (S)Phe psi(COCH2)(R,S)X [X = Ala (4), Orn (5)] and (S)Trp psi(COCH2)(R,S)Y [Y = Orn (6), Lys (7), Arg (8)] on aminopeptidase B (AP-B), and enkephalin-degrading enzymes [aminopeptidase N (APN) and neutral endopeptidase (NEP)] were compared with that of the model compound 1.
Gene_expression (effects) of aminopeptidase B associated with enkephalin
4) Confidence 0.13 Published 1992 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 1605710 Disease Relevance 0 Pain Relevance 0.17
Indeed, Ap-B processes glucagon into miniglucagon in the ?
Gene_expression (processes) of Ap-B
5) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.21 Pain Relevance 0.15
Mutagenesis of any of the three zinc binding ligands of the HEXXHX18E conserved motif (H325, H329, E348 in rat Ap-B sequence or of the critical general base of the peptidase reaction E326 led to complete loss of aminopeptidase activity (Table 3).
Gene_expression (sequence) of Ap-B
6) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.08 Pain Relevance 0.04
Addition of 0.2 M NaCl with either the purified rat testis Ap-B protein or the recombinant enzyme expressed in baculovirus system, results in a 3-time increase in activity [4,29].
Gene_expression (expressed) of Ap-B protein in testis
7) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
The rat Ap-B was detected with a specific anti-Ap-B polyclonal serum [4] at a dilution of 1:2000.
Gene_expression (detected) of Ap-B
8) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
Although this putative domain in Ap-B and LTA4H exhibits shorter ?
Gene_expression (exhibits) of Ap-B
9) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
The enzymatic properties of Ap-B and its expression pattern [4,18-22] lead to the hypothesis that this enzyme could be involved in inflammatory processes [23], development of tumours [24] and Type II diabetes [15].
Gene_expression (expression) of Ap-B associated with inflammation, diabetes mellitus and cancer
10) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.34 Pain Relevance 0.17
These patches, defined as clusters of neighbouring apolar atoms deemed accessible on a given surface, were investigated on Ap-B and LTA4H structures.
Spec (investigated) Gene_expression (structures) of Ap-B
11) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
Expression and purification of the E. coli recombinant rat Ap-B protein
Gene_expression (Expression) of Ap-B protein
12) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.08 Pain Relevance 0
VLP, MSC, CGD, MCB and TF participated in the construction of the Ap-B expression vector.
Gene_expression (expression) of Ap-B
13) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.05 Pain Relevance 0
Production of rat Ap-B in E. coli
Gene_expression (Production) of Ap-B
14) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.25 Pain Relevance 0.05
The rat Ap-B cDNA was expressed in E. coli and the purified recombinant enzyme was characterized. 18 mutants of the H325EXXHX18E348 Zn2+-binding motif were constructed and expressed.
Gene_expression (expressed) of Ap-B cDNA
15) Confidence 0.03 Published 2007 Journal BMC Biochem Section Abstract Doc Link PMC2241622 Disease Relevance 0.08 Pain Relevance 0.04
In this paper, we describe the production and purification of the rat Ap-B (rAp-B) in E. coli, the characterization of the recombinant protein and its catalytic properties.
Gene_expression (production) of Ap-B
16) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.06 Pain Relevance 0.03
The Ap-B RNP1 motif (K416GYCFVSY423) is found in a ?
Gene_expression (found) of Ap-B
17) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
Then, the recombinant rat Ap-B protein (rAp-B) was produced with this T7 promoter-driven plasmid in a BLi5 E. coli strain.
Gene_expression (produced) of Ap-B protein associated with sprains and strains
18) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0.10 Pain Relevance 0
The overall percentages of the different secondary structures differ (Ap-B: ?
Gene_expression (differ) of Ap-B
19) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
The recombinant rAp-B was produced with a NH2-terminal histidine tag and was characterized.
Gene_expression (produced) of rAp-B
20) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0.04

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