INT118716

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 7.25
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 98.56 Very High Very High Very High
Spinal cord 30 93.92 High High
Hippocampus 23 92.76 High High
cytokine 7 92.36 High High
cerebral cortex 10 92.24 High High
Inflammation 8 75.00 Quite High
Sciatica 1 25.00 Low Low
Dopamine 20 5.00 Very Low Very Low Very Low
Substantia nigra 13 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 316 99.60 Very High Very High Very High
Neuropathic Pain 1 98.56 Very High Very High Very High
Dementia 125 98.48 Very High Very High Very High
Disease 318 96.92 Very High Very High Very High
Alzheimer's Dementia 38 96.72 Very High Very High Very High
Supranuclear Palsy 30 96.56 Very High Very High Very High
Frontotemporal Dementia 97 95.08 Very High Very High Very High
Syndrome 31 94.52 High High
Lifespan 1 93.60 High High
Injury 7 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly, CNS axons in RW mice contained reduced levels of tau when compared with hWT mice, and this was linked to retarded axonal transport and increased accumulation of an insoluble pool of RW but not hWT tau.
Positive_regulation (increased) of tau
1) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15140937 Disease Relevance 1.21 Pain Relevance 0.14
IL-6, IL-8, MCP-1, tau, S100beta, and glial fibrillary acidic protein (GFAP) were elevated in a severity-dependent fashion.
Positive_regulation (elevated) of tau
2) Confidence 0.45 Published 2010 Journal J. Neurotrauma Section Abstract Doc Link 20038240 Disease Relevance 1.17 Pain Relevance 0.40
Since FTDP-17 can be caused by mutations in two different genes, FTDP-17T is now being used to refer to the disease in individuals with a mutation in Tau.
Positive_regulation (caused) of FTDP-17 associated with disease
3) Confidence 0.36 Published 2008 Journal Brain Section Body Doc Link PMC2702832 Disease Relevance 0.79 Pain Relevance 0
Similar findings of highly elevated CSF t-tau and p-tau181 have now been reported for some autopsy-confirmed DLB patients [93].Concentrations of both t-tau and p-tau do not correlate with the DLB disease duration [58].
Positive_regulation (elevated) of t-tau associated with parkinson's disease and disease
4) Confidence 0.05 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 2.03 Pain Relevance 0
Although CSF t-tau was elevated in the DLB group, there was no significant difference between the DLB and AD subjects (using the previous data from the AD patients).
Positive_regulation (s elevat) of t-tau associated with parkinson's disease and disease
5) Confidence 0.03 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 2.04 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox