INT11872

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Context Info
Confidence 0.87
First Reported 1985
Last Reported 1992
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 8
Disease Relevance 0
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rnpep) extracellular space (Rnpep) aging (Rnpep)
extracellular region (Rnpep) Golgi apparatus (Rnpep) plasma membrane (Rnpep)
Anatomy Link Frequency
brain 5
Rnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 41 100.00 Very High Very High Very High
Neuropeptide 8 99.14 Very High Very High Very High
Opioid 3 98.96 Very High Very High Very High
Dynorphin 3 97.68 Very High Very High Very High
substance P 3 96.36 Very High Very High Very High
Somatostatin 3 95.84 Very High Very High Very High
opiate 3 71.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kyotorphin was degraded by the aminopeptidase at pH 7.0, and the Vmax and Km values were 9.2 mumol/min/mg protein and 95 microM, respectively.
Protein_catabolism (degraded) of aminopeptidase
1) Confidence 0.87 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1777940 Disease Relevance 0 Pain Relevance 0.49
We studied the hydrolysis of a neuropeptide kyotorphin (L-Tyr-L-Arg) by an enkephalin-degrading aminopeptidase purified from cytosol of rat brain in vitro.
Protein_catabolism (degrading) of aminopeptidase in brain associated with neuropeptide and enkephalin
2) Confidence 0.56 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1777940 Disease Relevance 0 Pain Relevance 0.34
An enkephalin-degrading aminopeptidase from rat brain catalyzes the hydrolysis of a neuropeptide, kyotorphin (L-Tyr-L-Arg).
Protein_catabolism (degrading) of aminopeptidase in brain associated with neuropeptide and enkephalin
3) Confidence 0.56 Published 1991 Journal Chem. Pharm. Bull. Section Title Doc Link 1777940 Disease Relevance 0 Pain Relevance 0.59
Taken together, these results suggest a possible involvement of the enkephalin-degrading aminopeptidase in cytosolic degradation of kyotorphin in neuronal cells of rat brain.
Protein_catabolism (degrading) of aminopeptidase in brain associated with enkephalin
4) Confidence 0.56 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1777940 Disease Relevance 0 Pain Relevance 0.49
The enkephalin-degrading aminopeptidase is potently inhibited by opioid (alpha-neo-endorphin and dynorphin) as well as nonopioid (substance P, somatostatin, and angiotensin I) peptides in the range of 0.2-2.0 microM.
Protein_catabolism (degrading) of aminopeptidase associated with dynorphin, somatostatin, enkephalin, opioid and substance p
5) Confidence 0.55 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3886843 Disease Relevance 0 Pain Relevance 0.68
Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase.
Protein_catabolism (degrading) of aminopeptidase in brain associated with enkephalin
6) Confidence 0.55 Published 1985 Journal J. Neurochem. Section Title Doc Link 3886843 Disease Relevance 0 Pain Relevance 0.63
Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase.
Protein_catabolism (-) of aminopeptidase in brain associated with enkephalin
7) Confidence 0.55 Published 1985 Journal J. Neurochem. Section Title Doc Link 3886843 Disease Relevance 0 Pain Relevance 0.63
Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines.
Protein_catabolism (degrading) of aminopeptidase B associated with enkephalin
8) Confidence 0.07 Published 1992 Journal Arch. Pharm. (Weinheim) Section Title Doc Link 1605710 Disease Relevance 0 Pain Relevance 0.16

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