INT118734

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 70
Total Number 79
Disease Relevance 55.70
Pain Relevance 28.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
lung 6
spinal 5
microglia 3
adipose tissue 3
small intestine 2
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 938 100.00 Very High Very High Very High
Central nervous system 110 99.96 Very High Very High Very High
glial activation 96 99.96 Very High Very High Very High
cINOD 11 99.92 Very High Very High Very High
Neuritis 10 99.92 Very High Very High Very High
Spinal cord 373 99.84 Very High Very High Very High
Neuropathic pain 482 99.62 Very High Very High Very High
Cancer pain 1078 99.60 Very High Very High Very High
Eae 493 99.48 Very High Very High Very High
Arthritis 6 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 279 100.00 Very High Very High Very High
Obesity 504 99.92 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 24 99.72 Very High Very High Very High
Bone Cancer 1188 99.68 Very High Very High Very High
Neuropathic Pain 956 99.62 Very High Very High Very High
Arthritis 33 99.56 Very High Very High Very High
Injury 596 99.48 Very High Very High Very High
Stress 449 99.36 Very High Very High Very High
Hypersensitivity 401 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To construct a green fluorescent protein (GFP) tagged TLR4 expressing vector, total RNA was extracted from rat lung tissues using Tri-Reagent (TaKaRa, Japan).
Gene_expression (expressing) of TLR4 in lung
1) Confidence 0.78 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0.22 Pain Relevance 0.22
Our data showed that the spinal microglial activation markers mRNA, TLR4 mRNA and TLR4 protein expression were significantly elevated in the rat model of bone cancer pain.
Gene_expression (expression) of TLR4 in spinal associated with cancer pain and bone cancer
2) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.74 Pain Relevance 1.08
In a rat model of complete Freund's adjuvant-induced chronic pain, increased microglial activation, accompanied by upregulation of TLR4 mRNA expression and release of TNFa, IL-1?
Gene_expression (expression) of TLR4 mRNA associated with lasting pain
3) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.98 Pain Relevance 1.00
TLR4 protein expression was significantly reduced following treatment with TLR4 siRNA compared with mismatched siRNA treatment (Fig. 4A,C).
Gene_expression (expression) of TLR4
4) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.19 Pain Relevance 0.25
Our data showed that the spinal microglial activation markers mRNA, TLR4 mRNA and TLR4 protein expression were significantly elevated in the rat model of bone cancer pain.
Gene_expression (expression) of TLR4 mRNA in spinal associated with cancer pain and bone cancer
5) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.74 Pain Relevance 1.09
In a model of neuropathic pain, spinal microglia TLR4 mRNA expression is also increased after L5 nerve transection in rats [24].
Gene_expression (expression) of TLR4 mRNA in nerve associated with neuropathic pain
6) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.57 Pain Relevance 0.90
The most effective siRNA for knocking down TLR4 expression was siRNA439(n = 4, ANOVA1w, P < 0.001, post hoc Dunnett testing).


Gene_expression (expression) of TLR4
7) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.22 Pain Relevance 0.28
This suggests that expression of TLR4 mRNA was up-regulated by the induction of bone cancer.
Gene_expression (expression) of TLR4 mRNA associated with bone cancer
8) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.07 Pain Relevance 0.44
In addition to measuring the effect of the siRNA treatment on TLR4 mRNA, we also determined their effect TLR4 protein expression 48 h after transfection, by western blot analysis.
Spec (determined) Gene_expression (expression) of TLR4
9) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.24 Pain Relevance 0.30
These data suggest that TLR4 expression was significantly up-regulated in the bone cancer pain model caused by Walker 256 cells inoculation.


Gene_expression (expression) of TLR4 associated with cancer pain and bone cancer
10) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.84 Pain Relevance 0.50
Attenuation of TLR4 expression by siRNAs
Gene_expression (expression) of TLR4
11) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.64 Pain Relevance 0.56
As shown in the present study, the knockdown of TLR4 expression leads to attenuation of behavioral hypersensitivity, decreased glial activation, and decreased expression of proinflammatory cytokines.
Gene_expression (expression) of TLR4 associated with hypersensitivity, cytokine and glial activation
12) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.38 Pain Relevance 1.24
TLR4 expression increases in the bone cancer pain model
Gene_expression (expression) of TLR4 associated with cancer pain and bone cancer
13) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.22 Pain Relevance 0.58
In the central nervous system, TLR4 is predominantly expressed by microglia.
Gene_expression (expressed) of TLR4 in microglia associated with central nervous system
14) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.08 Pain Relevance 1.19
Increased susceptibility of small intestine to NSAID-provoked ulceration in rats with adjuvant-induced arthritis: involvement of enhanced expression of TLR4.
Gene_expression (expression) of TLR4 in small intestine associated with cinod and arthritis
15) Confidence 0.76 Published 2007 Journal Life Sci. Section Title Doc Link 17920637 Disease Relevance 0.61 Pain Relevance 0.39
These phenomena may be accounted for by the upregulation of iNOS/NO through the increased expression of TLR4 in the small intestine of arthritic rats.
Gene_expression (expression) of TLR4 in small intestine associated with arthritis
16) Confidence 0.76 Published 2007 Journal Life Sci. Section Abstract Doc Link 17920637 Disease Relevance 0.72 Pain Relevance 0.14
The expression of iNOS and TLR4 in the intestine was enhanced in arthritic rats as compared with normal rats.
Gene_expression (expression) of TLR4 in intestine associated with arthritis
17) Confidence 0.76 Published 2007 Journal Life Sci. Section Abstract Doc Link 17920637 Disease Relevance 0.80 Pain Relevance 0.26
Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis.
Gene_expression (Expression) of TLR4 associated with experimental autoimmune neuritis and neuritis
18) Confidence 0.75 Published 2007 Journal Neuroimmunomodulation Section Title Doc Link 18434754 Disease Relevance 0.66 Pain Relevance 0.59
Differences in the expression levels of Tlr4 in the whiskers area of the DA rats were significant at 2 and 3 dpi and in PVG at 1, 2 and 4 dpi.
Gene_expression (expression) of Tlr4 in whiskers
19) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.15 Pain Relevance 0.03
To identify the knockdown efficacy of different siRNA oligonucleotides, HEK-293 cells were cotransfected with pEGFPC1-TLR4 and siRNA (iRNA1-3, respectively) with lipofectamine2000 (Invitrogen, USA).
Gene_expression (cotransfected) of TLR4
20) Confidence 0.67 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0 Pain Relevance 0

General Comments

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