INT118735

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.24
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
spinal nerve 2
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 196 98.92 Very High Very High Very High
cytokine 56 97.08 Very High Very High Very High
allodynia 13 83.04 Quite High
Neuropathic pain 33 81.12 Quite High
IPN 20 79.44 Quite High
Pain 56 71.68 Quite High
Traumatic nerve injury 1 66.32 Quite High
wide dynamic range 1 65.52 Quite High
Inflammation 4 63.92 Quite High
Lasting pain 18 63.48 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 69 100.00 Very High Very High Very High
Bone Cancer 216 98.96 Very High Very High Very High
Neuropathic Pain 82 83.04 Quite High
Inflammatory Pain 20 79.44 Quite High
Pain 106 71.68 Quite High
Nervous System Injury 15 66.32 Quite High
INFLAMMATION 4 63.92 Quite High
Cancer 72 62.80 Quite High
Injury 4 59.36 Quite High
Polycystic Ovary Syndrome 28 48.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.
Positive_regulation (upregulated) of Transcription (expression) of ITGAM in spinal nerve
1) Confidence 0.49 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35
Our data also shows that transcription of the microglial activation markers, CD11b and CD14, was significantly elevated at the initiation phase of behavioral hypersensitivity, and moderately increased at the maintenance phase.
Positive_regulation (increased) of Transcription (transcription) of CD11b associated with hypersensitivity
2) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.33 Pain Relevance 0.84
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Positive_regulation (increase) of Transcription (expression) of CD11b associated with cancer pain and bone cancer
3) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58
Our data also shows that transcription of the microglial activation markers, CD11b and CD14, was significantly elevated at the initiation phase of behavioral hypersensitivity, and moderately increased at the maintenance phase.
Positive_regulation (elevated) of Transcription (transcription) of CD11b associated with hypersensitivity
4) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.20 Pain Relevance 0.75
CD11b mRNA expression was also higher at day 18 after inoculation relative to the normal and sham group (ANOVA1w, P < 0.05, post hoc Dunnett testing).
Positive_regulation (higher) of Transcription (expression) of CD11b
5) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.59 Pain Relevance 0.59

General Comments

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