INT118736

Context Info Confidence 0.49 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.42 Pain Relevance 0.35

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4) cytoplasm (Tlr4)

Anatomy Link Frequency spinal nerve 2 Tlr4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat allodynia 1 83.04 Neuropathic pain 1 75.00 Traumatic nerve injury 1 66.32 wide dynamic range 1 65.52 Lasting pain 2 63.48 Peripheral nerve injury 1 61.60 neuralgia 2 25.00

Disease Link Frequency Relevance Heat Neuropathic Pain 2 83.04 Hypersensitivity 1 76.00 Nervous System Injury 3 66.32 Pain 2 63.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.

Positive_regulation (upregulated) of Transcription (expression) of TLR4 in spinal nerve

1) Confidence 0.49 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35

General Comments

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