INT118738

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.39
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
Spinal 2
blood 1
spinal nerve 1
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 3 94.76 High High
Traumatic nerve injury 3 78.04 Quite High
Lasting pain 6 75.20 Quite High
Neuropathic pain 3 75.00 Quite High
wide dynamic range 3 63.44 Quite High
Peripheral nerve injury 3 59.52 Quite High
Neuritis 10 50.00 Quite Low
neuralgia 6 25.00 Low Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 94.76 High High
Hypersensitivity 3 87.72 High High
Experimental Autoimmune Neuritis 10 79.40 Quite High
Nervous System Injury 9 78.04 Quite High
Pain 6 75.20 Quite High
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.
Transcription (expression) of TLR4 in spinal nerve
1) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35
Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.
Transcription (levels) of TLR4 in Spinal
2) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32
The mRNA expression of TLR4 peaked at day 16, then decreased gradually, but at day 33, it was still higher than that of the CFA control group (p < 0.05); there were significant differences among the four time points (p < 0.05).
Transcription (xpression ) of TLR4
3) Confidence 0.69 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 18434754 Disease Relevance 0.07 Pain Relevance 0
The mRNA expression of TLR4 and TLR9 in spleen, sciatic nerve, peripheral blood monocytes and lymph nodes was detected by reverse transcriptase PCR dynamically.
Transcription (xpression ) of TLR4 in blood
4) Confidence 0.69 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 18434754 Disease Relevance 0.08 Pain Relevance 0
Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.
Transcription (levels) of toll-like receptor 4 in Spinal
5) Confidence 0.67 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32

General Comments

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