INT118738

Context Info Confidence 0.70 First Reported 2004 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 1.39 Pain Relevance 1.00

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4) cytoplasm (Tlr4)

Anatomy Link Frequency Spinal 2 blood 1 spinal nerve 1 Tlr4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat allodynia 3 94.76 Traumatic nerve injury 3 78.04 Lasting pain 6 75.20 Neuropathic pain 3 75.00 wide dynamic range 3 63.44 Peripheral nerve injury 3 59.52 Neuritis 10 50.00 neuralgia 6 25.00 Peripheral nervous system 2 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 6 94.76 Hypersensitivity 3 87.72 Experimental Autoimmune Neuritis 10 79.40 Nervous System Injury 9 78.04 Pain 6 75.20 Demyelinating Disease 2 5.00 Syndrome 2 5.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.

Transcription (expression) of TLR4 in spinal nerve

1) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35

Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.

Transcription (levels) of TLR4 in Spinal

2) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32

The mRNA expression of TLR4 peaked at day 16, then decreased gradually, but at day 33, it was still higher than that of the CFA control group (p < 0.05); there were significant differences among the four time points (p < 0.05).

Transcription (xpression ) of TLR4

3) Confidence 0.69 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 18434754 Disease Relevance 0.07 Pain Relevance 0

The mRNA expression of TLR4 and TLR9 in spleen, sciatic nerve, peripheral blood monocytes and lymph nodes was detected by reverse transcriptase PCR dynamically.

Transcription (xpression ) of TLR4 in blood

4) Confidence 0.69 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 18434754 Disease Relevance 0.08 Pain Relevance 0

Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.

Transcription (levels) of toll-like receptor 4 in Spinal

5) Confidence 0.67 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32

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