INT118739

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14) response to stress (Cd14)
Anatomy Link Frequency
spinal nerve 2
Cd14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 49 99.12 Very High Very High Very High
cytokine 14 97.08 Very High Very High Very High
allodynia 4 83.04 Quite High
Neuropathic pain 9 75.00 Quite High
Traumatic nerve injury 1 66.32 Quite High
wide dynamic range 1 65.52 Quite High
Lasting pain 6 63.48 Quite High
Peripheral nerve injury 2 61.60 Quite High
intrathecal 13 40.88 Quite Low
Brush evoked pain 8 33.24 Quite Low
Disease Link Frequency Relevance Heat
Bone Cancer 54 99.32 Very High Very High Very High
Neuropathic Pain 22 83.04 Quite High
Hypersensitivity 18 76.00 Quite High
Nervous System Injury 6 66.32 Quite High
Pain 28 63.48 Quite High
Cancer 18 58.60 Quite High
Polycystic Ovary Syndrome 7 48.20 Quite Low
Cancer Pain 2 24.96 Low Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.
Positive_regulation (upregulated) of Transcription (expression) of CD14 in spinal nerve
1) Confidence 0.64 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Positive_regulation (increase) of Transcription (levels) of CD14 associated with cancer pain and bone cancer
2) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58

General Comments

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