INT118740

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 5.11
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
Spinal 2
spinal nerve 1
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 196 98.92 Very High Very High Very High
Dorsal horn 6 97.12 Very High Very High Very High
cytokine 56 96.24 Very High Very High Very High
allodynia 18 94.76 High High
Neuropathic pain 38 87.16 High High
Brush evoked pain 34 79.48 Quite High
Traumatic nerve injury 3 78.04 Quite High
Lasting pain 22 75.20 Quite High
IPN 20 70.00 Quite High
intrathecal 54 69.28 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 216 98.96 Very High Very High Very High
Nervous System Injury 27 98.84 Very High Very High Very High
Hypersensitivity 71 97.44 Very High Very High Very High
Neuropathic Pain 94 94.76 High High
Pain 110 75.20 Quite High
Inflammatory Pain 20 70.00 Quite High
Cancer 72 57.76 Quite High
INFLAMMATION 4 54.48 Quite High
Injury 4 49.92 Quite Low
Polycystic Ovary Syndrome 28 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.
Transcription (expression) of ITGAM in spinal nerve
1) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35
Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.
Transcription (levels) of ITGAM in Spinal
2) Confidence 0.52 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32
Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.
Transcription (levels) of integrin alpha M in Spinal
3) Confidence 0.52 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32
This was confirmed by qPCR analysis of IBA-1 mRNA and mRNA of other microglial markers, integrin-alpha M, MHC-II DMalpha and MHC-II DMbeta.
Transcription (analysis) of integrin-alpha M
4) Confidence 0.44 Published 2007 Journal Pain Section Abstract Doc Link 17110040 Disease Relevance 0.86 Pain Relevance 0.67
CD11b mRNA expression was also higher at day 18 after inoculation relative to the normal and sham group (ANOVA1w, P < 0.05, post hoc Dunnett testing).
Transcription (expression) of CD11b
5) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.59 Pain Relevance 0.59
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Transcription (expression) of CD11b associated with cancer pain and bone cancer
6) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Transcription (levels) of CD11b associated with cancer pain and bone cancer
7) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.62 Pain Relevance 0.58
Our data also shows that transcription of the microglial activation markers, CD11b and CD14, was significantly elevated at the initiation phase of behavioral hypersensitivity, and moderately increased at the maintenance phase.
Transcription (transcription) of CD11b associated with hypersensitivity
8) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.12 Pain Relevance 0.73

General Comments

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