INT118758

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Per2) protein binding transcription factor activity (Per2) cytoplasm (Per2)
signal transducer activity (Per2)
Anatomy Link Frequency
SCN 2
Per2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 4 100.00 Very High Very High Very High
tetrodotoxin 10 99.98 Very High Very High Very High
Action potential 4 99.60 Very High Very High Very High
adenocard 9 11.28 Low Low
Hippocampus 6 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 67.12 Quite High
Aging 27 40.36 Quite Low
Sleep Disorders 75 5.00 Very Low Very Low Very Low
Cognitive Disorder 22 5.00 Very Low Very Low Very Low
Obesity 16 5.00 Very Low Very Low Very Low
Hypertension 12 5.00 Very Low Very Low Very Low
Apnoea 10 5.00 Very Low Very Low Very Low
Sleep Initiation And Maintenance Disorders 9 5.00 Very Low Very Low Very Low
Restless Legs Syndrome 7 5.00 Very Low Very Low Very Low
Cardiovascular Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Light pulses, which induce smaller phase shifts in old animals than in young, lead to decreased induction of Per1, but not of Per2, in the SCN of old hamsters (Kolker et al., 2003).
Negative_regulation (decreased) of Positive_regulation (induction) of Per2
1) Confidence 0.09 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.07 Pain Relevance 0
These results demonstrate that action potentials in the SCN are not necessary for NMDA receptor activation to increase Per1 and Per2 mRNA levels, but are necessary for NMDA receptor activation to decrease pineal melatonin levels.
Neg (not) Negative_regulation (necessary) of Positive_regulation (increase) of Per2 in SCN associated with action potential and nmda receptor
2) Confidence 0.07 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15147314 Disease Relevance 0 Pain Relevance 0.61
TTX inhibited the ability of light to increase Per1 and Per2 mRNA levels and suppress pineal melatonin levels.
Negative_regulation (inhibited) of Positive_regulation (increase) of Per2 associated with tetrodotoxin
3) Confidence 0.07 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15147314 Disease Relevance 0 Pain Relevance 0.62

General Comments

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