INT118761

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.68
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Per2) protein binding transcription factor activity (Per2) cytoplasm (Per2)
signal transducer activity (Per2)
Anatomy Link Frequency
SCN 2
pineal gland 1
Per2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 15 99.70 Very High Very High Very High
Neurotransmitter 288 99.40 Very High Very High Very High
tetrodotoxin 20 99.30 Very High Very High Very High
Glutamate 70 99.12 Very High Very High Very High
Action potential 11 98.76 Very High Very High Very High
bDMF 16 98.56 Very High Very High Very High
antagonist 25 96.28 Very High Very High Very High
Serotonin 18 75.16 Quite High
Raphe 25 73.24 Quite High
gABA 98 69.16 Quite High
Disease Link Frequency Relevance Heat
Disease 32 77.20 Quite High
Thyroid Disease 1 76.80 Quite High
Targeted Disruption 13 67.12 Quite High
Chronic Disease 4 60.56 Quite High
Hypertension 39 58.56 Quite High
Diabetes Mellitus 11 57.44 Quite High
Depression 25 56.32 Quite High
Cancer 16 50.68 Quite High
Sleep Disorders 99 42.64 Quite Low
Aging 33 39.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is now known that light entrainment of the clock involves the induction of c-Fos [274] and clock genes per1 and per2 [275-277].
Positive_regulation (induction) of per2
1) Confidence 0.42 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.16 Pain Relevance 0.24
Possible genes for glutamate and PACAP thus appear to be the clock genes per1 and per2, which are induced in the SCN by light, glutamate and PACAP at night.
Positive_regulation (induced) of per2 associated with glutamate
2) Confidence 0.30 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.38 Pain Relevance 0.26
Possible targets for some of the neurotransmitters are the clock genes per1 and per2, which are induced in the SCN by light or by neurotransmitters, at night.
Positive_regulation (induced) of per2 associated with neurotransmitter
3) Confidence 0.30 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.73
Among these, lithium upregulated the period homolog 2 (Per2), the secretogranin II (Scg2), the BDNF and the IMPA1 genes.
Positive_regulation (upregulated) of Per2 associated with bdmf
4) Confidence 0.28 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.08 Pain Relevance 0.05
Light pulses, which induce smaller phase shifts in old animals than in young, lead to decreased induction of Per1, but not of Per2, in the SCN of old hamsters (Kolker et al., 2003).
Positive_regulation (induction) of Per2
5) Confidence 0.15 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.07 Pain Relevance 0
The present study investigated whether the ability of light to increase Per1 and Per2 mRNA levels and suppress pineal melatonin levels requires sodium-dependent action potentials in the SCN.
Positive_regulation (increase) of Per2 in SCN associated with action potential
6) Confidence 0.11 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15147314 Disease Relevance 0 Pain Relevance 0.45
Light presented during the night acutely increases mRNA levels of the circadian clock genes Per1 and Per2 in the SCN, and acutely suppresses melatonin levels in the pineal gland.
Positive_regulation (increases) of Per2 in pineal gland
7) Confidence 0.11 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15147314 Disease Relevance 0 Pain Relevance 0.37
These results demonstrate that action potentials in the SCN are not necessary for NMDA receptor activation to increase Per1 and Per2 mRNA levels, but are necessary for NMDA receptor activation to decrease pineal melatonin levels.
Positive_regulation (increase) of Per2 in SCN associated with action potential and nmda receptor
8) Confidence 0.11 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15147314 Disease Relevance 0 Pain Relevance 0.60
TTX inhibited the ability of light to increase Per1 and Per2 mRNA levels and suppress pineal melatonin levels.
Positive_regulation (increase) of Per2 associated with tetrodotoxin
9) Confidence 0.08 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15147314 Disease Relevance 0 Pain Relevance 0.62

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