INT118782

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Context Info
Confidence 0.94
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.46
Pain Relevance 6.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
spinal cord 3
cleavage 1
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 334 100.00 Very High Very High Very High
Spinal cord 30 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
tail-flick 12 97.44 Very High Very High Very High
Antinociceptive 18 95.96 Very High Very High Very High
intrathecal 6 94.96 High High
imagery 1 50.00 Quite Low
Analgesic 12 25.00 Low Low
agonist 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Nociception 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Reprotox - General 2 2 5.00 Very Low Very Low Very Low
Tics 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that degradation of SP by spinal endopeptidase-24.11 may lead to the formation of SP(1-7), which has an ability to produce antinociceptive effects at the mouse spinal cord level.
Protein_catabolism (degradation) of SP in spinal cord associated with antinociceptive, spinal cord and substance p
1) Confidence 0.94 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.05 Pain Relevance 1.20
In contrast, captopril (a specific inhibitor of angiotensin-converting enzyme), bestatin (a specific inhibitor of aminopeptidase) and Z-321 (a specific inhibitor of prolylendopeptidase) showed little effect on the degradation of SP.
Protein_catabolism (degradation) of SP associated with substance p
2) Confidence 0.62 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.08 Pain Relevance 1.11
The accumulation of the major cleavage products was strongly inhibited by phosphoramidon and thirophan, as well as the initial cleavage of SP.
Protein_catabolism (cleavage) of SP in cleavage associated with substance p
3) Confidence 0.54 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.07 Pain Relevance 1.22
Thus, endopeptidase-24.11 plays a major role in SP degradation in the mouse spinal cord.
Protein_catabolism (degradation) of SP in spinal cord associated with spinal cord and substance p
4) Confidence 0.54 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.07 Pain Relevance 1.23
Degradation of SP was inhibited by a metal chelator, o-phenanthroline, and also by specific inhibitors of endopeptidase-24.11, thiorphan and phosphoramidon.
Protein_catabolism (Degradation) of SP associated with substance p
5) Confidence 0.54 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.09 Pain Relevance 0.89
Substance P (SP), which is known as a pain transmitter or modulator in the spinal cord, was degraded by the synaptic membranes of the mouse spinal cord.
Protein_catabolism (degraded) of SP in spinal cord associated with pain, spinal cord and substance p
6) Confidence 0.54 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.10 Pain Relevance 0.79
Sigmoidal (Hill, 3 parameter) regression was then performed on the data to determine the IC50, the concentration of fluorescent analog required to inhibit the binding of radiolabeled SP by 50 %, for each SP analog.


Protein_catabolism (radiolabeled) of SP associated with substance p
7) Confidence 0.06 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.50

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