INT118791

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 15.51
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
artery endothelium 1
bile duct 1
HL-60 1
fibroblasts 1
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 4 100.00 Very High Very High Very High
Gabapentin 17 99.48 Very High Very High Very High
antagonist 18 94.88 High High
Glutamate receptor 6 93.60 High High
palliative 2 90.96 High High
COX-2 inhibitor 203 90.76 High High
cytokine 341 88.68 High High
Glutamate 2 77.72 Quite High
gABA 4 77.16 Quite High
Neuropathic pain 1 76.96 Quite High
Disease Link Frequency Relevance Heat
Stress 43 100.00 Very High Very High Very High
Hypoxia 20 100.00 Very High Very High Very High
Bile Duct Neoplasms 13 100.00 Very High Very High Very High
Tuberous Sclerosis 3 100.00 Very High Very High Very High
Cancer 644 99.88 Very High Very High Very High
Reprotox - General 1 11 99.60 Very High Very High Very High
Lung Cancer 20 98.52 Very High Very High Very High
Cervical Cancer 6 98.00 Very High Very High Very High
Apoptosis 470 97.84 Very High Very High Very High
Targeted Disruption 63 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
AKT Binding (associated) of in bile duct associated with bile
1) Confidence 0.48 Published 2004 Journal Cancer Res. Section Title Doc Link 15150102 Disease Relevance 0.86 Pain Relevance 0.19
Affinity precipitation assays showed that gabapentin-lactam increased the GTP binding of the small GTPases Rac and Cdc42, which facilitate branch addition.
Rac Binding (binding) of associated with gabapentin
2) Confidence 0.47 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16844845 Disease Relevance 0.15 Pain Relevance 1.11
Furthermore, Par-4 has been shown to be inactivated by AKT1 in prostate cancer cells, and a Par-4/AKT1 interaction is widely found in prostate cancer, lung cancer, cervical cancer, as well as in benign prostatic hyperplasia and normal human embryonic lung fibroblasts [19].
AKT1 Binding (interaction) of in fibroblasts associated with cervical cancer, benign prostatic hypertrophy, lung cancer and reprotox - general 1
3) Confidence 0.39 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 1.81 Pain Relevance 0
Pharmacological and genetic studies revealed a potential mechanistic link between Akt/Mcl-1 and STAT-3/Mcl-1 signaling pathways and indomethacin-induced cytotoxicity.
Akt Binding (link) of
4) Confidence 0.36 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19250643 Disease Relevance 0.66 Pain Relevance 0.13
To prove further the relationship between Akt, I?
Akt Binding (relationship) of
5) Confidence 0.28 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.24 Pain Relevance 0
Previously, we have shown that phorphylated Akt (pAkt) interacts with and phosphorylates telomerase in canine LEC that have undergone EMT, but not in normal canine LEC [23,24].
Akt Binding (interacts) of
6) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.64 Pain Relevance 0.04
This includes three induced by DMSO (Akt, p27, PTEN) and seven by ATRA (RXR-?
Akt Binding (seven) of
7) Confidence 0.25 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.24 Pain Relevance 0
Expression of pAkt and telomerase activity follow irradiation and AR-12 treatment
pAkt Binding (activity) of
8) Confidence 0.22 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.27 Pain Relevance 0.03
As evaluated by immunohistochemisty, normal canine LEC had minimal to no detectable pAkt protein present (Figure 1A), while immunostaining for pAkt was strong predominantly in the cytoplasm of naturally occurring cataractous canine LEC (Figure 1B) and clinical samples of canine PCO (Figure 1C).
pAkt Binding (immunostaining) of associated with capsule opacification
9) Confidence 0.22 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.25 Pain Relevance 0.03
There was positive immunoreactivity for TERT and pAkt in all treatment groups, but a subjective decrease in staining was observed in the 7.5 ?
pAkt Binding (immunoreactivity) of
10) Confidence 0.22 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.13 Pain Relevance 0
Previously, we have shown that phorphylated Akt (pAkt) interacts with and phosphorylates telomerase in canine LEC that have undergone EMT, but not in normal canine LEC [23,24].
pAkt Binding (interacts) of
11) Confidence 0.22 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.64 Pain Relevance 0.04
Passing the remainder of the supernatant through CRIB-specific Streptavidin-agarose (Sigma-Aldrich, UK) beads allowed the purification of the lysate by binding only GTP-bound RAC.
RAC Binding (binding) of
12) Confidence 0.22 Published 2008 Journal Eplasty Section Body Doc Link PMC2311454 Disease Relevance 0 Pain Relevance 0
RAC activity increases in KFs when compared with NFs.
RAC Binding (activity) of
13) Confidence 0.19 Published 2008 Journal Eplasty Section Abstract Doc Link PMC2311454 Disease Relevance 0.67 Pain Relevance 0
Activated AKT phosphorylates and inhibits tuberous sclerosis complex (TSC) and removes its inhibitory effect on mTOR.18,19
AKT Binding (removes) of associated with tuberous sclerosis
14) Confidence 0.18 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.72 Pain Relevance 0
Activated AKT phosphorylates and inhibits tuberous sclerosis complex (TSC) and removes its inhibitory effect on mTOR.18,19
AKT Binding (inhibits) of associated with tuberous sclerosis
15) Confidence 0.18 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.67 Pain Relevance 0
The natural product rapamycin binds to an intracellular protein known as FK506-binding protein 12 (FKBP12) and the resultant protein-drug complex inhibits the kinase activity of mTOR.16 mTOR is a highly conserved intracellular multi functional signal transduction serine-threonine kinase, and is a key regulatory protein in cancer that recognizes stress signals (eg, nutrient and energy depletion, oxidative or hypoxic stress, and proliferative and survival signals) via the phosphotidylinositol 3 kinase-protein kinase (PI3K-AKT) pathway.
AKT Binding (recognizes) of associated with stress, hypoxia and cancer
16) Confidence 0.18 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 1.03 Pain Relevance 0
RAC activity
RAC Binding (activity) of
17) Confidence 0.17 Published 2008 Journal Eplasty Section Body Doc Link PMC2311454 Disease Relevance 0.37 Pain Relevance 0
Indeed, celecoxib was able to directly bind and inhibit PKB/Akt, which plays an important role in cell proliferation and in apoptosis.
PKB Binding (bind) of associated with apoptosis
18) Confidence 0.16 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.73 Pain Relevance 0.14
Indeed, celecoxib was able to directly bind and inhibit PKB/Akt, which plays an important role in cell proliferation and in apoptosis.
Akt Binding (bind) of associated with apoptosis
19) Confidence 0.16 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.74 Pain Relevance 0.14
No significant difference was observed between any treatment groups for mRNA expression for PKB, mTOR, p70S6k, GSK-3?
PKB Binding (p70S6k) of
20) Confidence 0.12 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

General Comments

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