INT118792

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.73
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 79 97.08 Very High Very High Very High
mu opioid receptor 5 91.52 High High
Bile 2 75.00 Quite High
opiate 9 74.16 Quite High
palliative 3 69.68 Quite High
antagonist 15 66.28 Quite High
Opioid 5 65.32 Quite High
narcan 1 52.16 Quite High
imagery 17 38.00 Quite Low
cytokine 18 36.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 60 99.96 Very High Very High Very High
Capsule Opacification 57 99.12 Very High Very High Very High
Bile Duct Neoplasms 13 99.12 Very High Very High Very High
Hypoxia 31 98.96 Very High Very High Very High
Cancer 33 96.52 Very High Very High Very High
Death 15 94.80 High High
Targeted Disruption 13 88.72 High High
Cardiovascular Disease 1 81.76 Quite High
Prostate Cancer 3 75.76 Quite High
Hyperplasia 2 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, to evaluate the role of AKT activation in the regulation of BDC cell radiosensitivity, clonogenic assays were performed using the phosphatidylinositol 3'-kinase inhibitor LY294002 with and without irradiation.
Regulation (role) of Positive_regulation (activation) of AKT associated with bile duct neoplasms
1) Confidence 0.61 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150102 Disease Relevance 1.04 Pain Relevance 0.13
Various PI 3-kinase inhibitors such as Wortmannin, LY294002 and dominant-negative Akt expression vector were used to fully prove the involvement of PI 3-K/Akt pathway in the regulation of NF-?
Regulation (involvement) of Positive_regulation (pathway) of Akt
2) Confidence 0.39 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.21 Pain Relevance 0
Temsirolimus and rapamycin inhibit the downstream target of activated Akt, mTOR Complex 1 [1,15,26].
Regulation (target) of Positive_regulation (activated) of Akt
3) Confidence 0.18 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.67
This finding concurs with our immunoblotting data by demonstrating the importance of Akt and nAChR activation for cell survival during hypoxia.


Regulation (importance) of Positive_regulation (activation) of Akt associated with hypoxia
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.78 Pain Relevance 0.29
After H2O2 treatment, the cells were analyzed by immunoblotting (IB) to determine the effect of the above inhibitors on activation of ERK (A), PKB (B), and APP processing (C).
Spec (determine) Regulation (effect) of Positive_regulation (activation) of PKB
5) Confidence 0.09 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.07 Pain Relevance 0
To investigate the role of the Akt pathway in neurotrophin induction of IL-6, BMSC were pre-treated as described above with Akt VIII, a specific Akt inhibitor, for 2 hrs prior to stimulation with NGF or BDNF.
Spec (investigate) Regulation (role) of Spec (investigate) Positive_regulation (pathway) of Akt
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.12 Pain Relevance 0
Our data suggest that celecoxib is a more potent inhibitor of PCO formation ex vivo, potentially through the increased Akt regulated apoptosis.
Regulation (regulated) of Positive_regulation (increased) of Akt associated with capsule opacification and apoptosis
7) Confidence 0.08 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.99 Pain Relevance 0
Ca2+-regulated Rac activation
Regulation (regulated) of Positive_regulation (activation) of Rac
8) Confidence 0.05 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.03
The activation of Rac by a chemoattractant has been reported to be independent on [Ca2+]c changes, but relevant experiments have been performed in Ca2+-free buffer [164].
Neg (independent) Regulation (independent) of Positive_regulation (activation) of Rac
9) Confidence 0.05 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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