INT118812

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
RVM 1
Cck (Rattus norvegicus)
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 10 100.00 Very High Very High Very High
Rostral ventromedial medulla 7 100.00 Very High Very High Very High
Thermal hyperalgesia 1 98.96 Very High Very High Very High
Opioid 5 97.04 Very High Very High Very High
Hyperalgesia 2 96.20 Very High Very High Very High
withdrawal 1 87.32 High High
Pain 2 79.36 Quite High
Antinociceptive 1 68.48 Quite High
Morphine 1 65.72 Quite High
Analgesic 2 63.92 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 98.96 Very High Very High Very High
Pain 2 79.36 Quite High
Nociception 1 77.20 Quite High
Neuropathic Pain 1 53.48 Quite High
INFLAMMATION 1 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that direct, selective activation of RVM on-cells by CCK is sufficient to produce thermal hyperalgesia and indicate that the anti-opioid and pronociceptive effects of this peptide are mediated by actions on different RVM cell classes.
CCK Positive_regulation (activation) of RVM in RVM associated with thermal hyperalgesia, opioid, cholecystokinin and rostral ventromedial medulla
1) Confidence 0.21 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 15152023 Disease Relevance 0.65 Pain Relevance 1.46

General Comments

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