INT118817

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.44
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Apoc4) extracellular region (Apoc4)
Anatomy Link Frequency
macrophages 3
surface structure 1
Apoc4 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 126 99.58 Very High Very High Very High
rheumatoid arthritis 2 97.64 Very High Very High Very High
cytokine 82 92.88 High High
Inflammation 110 89.40 High High
Inflammatory response 28 75.68 Quite High
Central nervous system 8 70.44 Quite High
Inflammatory mediators 6 64.88 Quite High
Angina 3 54.32 Quite High
Intracerebroventricular 3 29.04 Quite Low
Migraine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Psoriasis 212 99.84 Very High Very High Very High
Stroke 11 99.36 Very High Very High Very High
Disease 60 99.28 Very High Very High Very High
Rheumatoid Arthritis 4 97.80 Very High Very High Very High
Systemic Lupus Erythematosus 6 97.28 Very High Very High Very High
Renal Failure 2 95.32 Very High Very High Very High
Atherosclerosis 36 94.76 High High
Diabetes Mellitus 6 94.72 High High
Myocardial Infarction 8 93.28 High High
Targeted Disruption 11 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The precipitating factors for the occurrence of stroke are the presence of beta 2-GPI-dependent aCL, a GPL aCL level of more than 40, and the simultaneous presence of lupus anticoagulant.
Positive_regulation (dependent) of aCL associated with stroke and systemic lupus erythematosus
1) Confidence 0.45 Published 2003 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15152454 Disease Relevance 1.07 Pain Relevance 0
et's disease, and psoriasis was suggested [51]. aCL level is increased in psoriatic patients.
Positive_regulation (increased) of aCL associated with psoriasis and disease
2) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.88 Pain Relevance 0.19
2-GP1-dependent anticardiolipin antibodies (aCL), as a consequence of structural similarity between ox-LDL surface structure and ?
Positive_regulation (dependent) of aCL in surface structure
3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.53 Pain Relevance 0.22
B activity increases in both cell lines, but the response is more augmented in the apoE4 macrophages.
Positive_regulation (augmented) of apoE4 in macrophages
4) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.53 Pain Relevance 0.33
Here, for the first time, we show that HO-1 levels are significantly increased in apoE4-macrophages.
Positive_regulation (increased) of apoE4-macrophages in macrophages
5) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.89 Pain Relevance 0.20
B pathway activation in the apoE4- versus the apoE3-macrophages (Fig. 3A).
Positive_regulation (activation) of apoE4 in macrophages
6) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.06 Pain Relevance 0.25
Under these conditions, a greater number of apoE4 molecules were associated with EM than apoE3 molecules.
Positive_regulation (number) of apoE4
7) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.49 Pain Relevance 0.04

General Comments

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